Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
spr1966Conserved hypothetical protein. (764 aa)    
Predicted Functional Partners:
spr1954
Hypothetical protein.
 
  
  0.975
spr1498
Conserved hypothetical protein; Putative large secreted protein.
  
  
 
0.923
spr1965
Hypothetical protein.
 
    0.801
pfbA
Hypothetical protein; Acts as a fibronectin-dependent adhesin and invasin. Binds host (in this case human) fibronectin, plasmin, plasminogen, and human serum albumin. Where the bacteria adhere to human cells there is major recruitment of microvilli which seem to fuse to cover the streptococcal chains. Antibodies to this protein reduce bacterial growth in human blood.
 
 
 0.798
fucU
Fucose pathway protein, function unknown; Belongs to the RbsD / FucU family.
  
    0.776
bgaA
Beta-galactosidase precursor.
 
   
 0.774
PTS-EII-19
Phosphotransferase system sugar-specific EII component.
  
    0.748
fucI
L-fucose isomerase; Converts the aldose L-fucose into the corresponding ketose L- fuculose.
 
    0.715
PTS-EII-21
Phosphotransferase system sugar-specific EII component.
  
    0.683
PTS-EII-22
Phosphotransferase system sugar-specific EII component.
  
    0.682
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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