Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
fcsKFucose kinase. (482 aa)    
Predicted Functional Partners:
fucI
L-fucose isomerase; Converts the aldose L-fucose into the corresponding ketose L- fuculose.
 
 
 0.991
fcsR
Regulator of fucose operon.
 
   
 0.957
fucA
L-fuculose phosphate aldolase.
 
 
 0.948
fucU
Fucose pathway protein, function unknown; Belongs to the RbsD / FucU family.
 
  
 0.886
czcD
Cation diffusion facilitator transporter - heavy metal transport.
   
    0.692
PTS-EII-22
Phosphotransferase system sugar-specific EII component.
  
  
 0.664
spr1966
Conserved hypothetical protein.
 
    0.615
PTS-EII-21
Phosphotransferase system sugar-specific EII component.
  
  
 0.604
fruA
Fructose specific-phosphotransferase system IIBC component.
     
 0.590
spr1965
Hypothetical protein.
 
    0.562
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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