Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
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[Homology]
Score
adcRTranscriptional repressor for Zn(2+)-responsive expression. (166 aa)    
Predicted Functional Partners:
phtD
Pneumococcal histidine triad protein D precursor.
   
  
 0.999
spr0909
Hypothetical protein.
   
    0.999
adcA
ABC transporter substrate-binding protein - Zinc (Zn2+) transport; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability; Belongs to the bacterial solute-binding protein 9 family.
  
  
 0.999
adcB
ABC transporter membrane-spanning permease - Zinc (Zn2+) transport.
  
  
 0.999
adcC
ABC transporter ATP-binding domain - Zinc (Zn2+) permease; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability (By similarity).
  
  
 0.999
lmb
Lipoprotein; Belongs to the bacterial solute-binding protein 9 family.
  
  
 0.991
copY
COPAB ATPases metal-fist type repressor.
     
 0.930
czcD
Cation diffusion facilitator transporter - heavy metal transport.
  
  
 0.894
phtA
Pneumococcal histidine triad protein A precursor.
      
 0.888
phtE
Pneumococcal histidine triad protein E precursor.
      
 0.886
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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