close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
adcRTranscriptional repressor for Zn(2+)-responsive expression. (166 aa)    
Predicted Functional Partners:
phtD
Pneumococcal histidine triad protein D precursor.
   
  
 0.999
spr0909
Hypothetical protein.
   
    0.999
adcA
ABC transporter substrate-binding protein - Zinc (Zn2+) transport; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability; Belongs to the bacterial solute-binding protein 9 family.
  
  
 0.999
adcB
ABC transporter membrane-spanning permease - Zinc (Zn2+) transport.
  
  
 0.999
adcC
ABC transporter ATP-binding domain - Zinc (Zn2+) permease; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability (By similarity).
  
  
 0.999
lmb
Lipoprotein; Belongs to the bacterial solute-binding protein 9 family.
  
  
 0.992
marR
Metalloregulator.
   
  
 0.926
phtA
Pneumococcal histidine triad protein A precursor.
      
 0.879
czcD
Cation diffusion facilitator transporter - heavy metal transport.
  
  
 0.875
phtE
Pneumococcal histidine triad protein E precursor.
      
 0.865
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.