Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
pspCCholine binding protein A. (701 aa)    
Predicted Functional Partners:
phtD
Pneumococcal histidine triad protein D precursor.
  
 
 0.943
ply
Pneumolysin (sulfhydryl-activated toxin that lyses cholesterol containing membranes); Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity).
  
 
 0.942
nanA
Sialidase A precursor (neuraminidase A); Belongs to the glycosyl hydrolase 33 family.
   
  
 0.929
phtE
Pneumococcal histidine triad protein E precursor.
  
 
 0.903
psaA
ABC transporter substrate-binding protein - manganese transport; Part of an ATP-driven transport system; Belongs to the bacterial solute-binding protein 9 family. Lipoprotein receptor antigen (Lrai) subfamily.
      
 0.892
flpA
Fibronectin-binding protein-like protein A; Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.
   
  
 0.891
zmpB
Zinc metalloprotease; Similar to IgA1 protease.
  
  
 0.890
nanB
Sialidase B precursor (neuraminidase B).
      
 0.817
phtA
Pneumococcal histidine triad protein A precursor.
  
 
 0.784
cbpG
Choline binding protein G.
  
  
 0.745
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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