| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| flpA | iga | spr0868 | spr1042 | Fibronectin-binding protein-like protein A; Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits. | Immunoglobulin A1 protease; Zinc metalloproteinase which cleaves human immunoglobulin A1 (IgA1) in the hinge region. | 0.603 |
| flpA | nanA | spr0868 | spr1536 | Fibronectin-binding protein-like protein A; Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits. | Sialidase A precursor (neuraminidase A); Belongs to the glycosyl hydrolase 33 family. | 0.925 |
| flpA | phtD | spr0868 | spr0907 | Fibronectin-binding protein-like protein A; Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits. | Pneumococcal histidine triad protein D precursor. | 0.596 |
| flpA | phtE | spr0868 | spr0908 | Fibronectin-binding protein-like protein A; Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits. | Pneumococcal histidine triad protein E precursor. | 0.518 |
| flpA | ply | spr0868 | spr1739 | Fibronectin-binding protein-like protein A; Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits. | Pneumolysin (sulfhydryl-activated toxin that lyses cholesterol containing membranes); Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity). | 0.951 |
| flpA | psaA | spr0868 | spr1494 | Fibronectin-binding protein-like protein A; Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits. | ABC transporter substrate-binding protein - manganese transport; Part of an ATP-driven transport system; Belongs to the bacterial solute-binding protein 9 family. Lipoprotein receptor antigen (Lrai) subfamily. | 0.925 |
| flpA | pspC | spr0868 | spr1995 | Fibronectin-binding protein-like protein A; Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits. | Choline binding protein A. | 0.887 |
| flpA | zmpB | spr0868 | spr0581 | Fibronectin-binding protein-like protein A; Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits. | Zinc metalloprotease; Similar to IgA1 protease. | 0.661 |
| iga | flpA | spr1042 | spr0868 | Immunoglobulin A1 protease; Zinc metalloproteinase which cleaves human immunoglobulin A1 (IgA1) in the hinge region. | Fibronectin-binding protein-like protein A; Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits. | 0.603 |
| iga | nanA | spr1042 | spr1536 | Immunoglobulin A1 protease; Zinc metalloproteinase which cleaves human immunoglobulin A1 (IgA1) in the hinge region. | Sialidase A precursor (neuraminidase A); Belongs to the glycosyl hydrolase 33 family. | 0.834 |
| iga | pck | spr1042 | spr1147 | Immunoglobulin A1 protease; Zinc metalloproteinase which cleaves human immunoglobulin A1 (IgA1) in the hinge region. | Choline kinase. | 0.409 |
| iga | ply | spr1042 | spr1739 | Immunoglobulin A1 protease; Zinc metalloproteinase which cleaves human immunoglobulin A1 (IgA1) in the hinge region. | Pneumolysin (sulfhydryl-activated toxin that lyses cholesterol containing membranes); Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity). | 0.807 |
| iga | psaA | spr1042 | spr1494 | Immunoglobulin A1 protease; Zinc metalloproteinase which cleaves human immunoglobulin A1 (IgA1) in the hinge region. | ABC transporter substrate-binding protein - manganese transport; Part of an ATP-driven transport system; Belongs to the bacterial solute-binding protein 9 family. Lipoprotein receptor antigen (Lrai) subfamily. | 0.650 |
| iga | pspC | spr1042 | spr1995 | Immunoglobulin A1 protease; Zinc metalloproteinase which cleaves human immunoglobulin A1 (IgA1) in the hinge region. | Choline binding protein A. | 0.721 |
| iga | zmpB | spr1042 | spr0581 | Immunoglobulin A1 protease; Zinc metalloproteinase which cleaves human immunoglobulin A1 (IgA1) in the hinge region. | Zinc metalloprotease; Similar to IgA1 protease. | 0.733 |
| nanA | flpA | spr1536 | spr0868 | Sialidase A precursor (neuraminidase A); Belongs to the glycosyl hydrolase 33 family. | Fibronectin-binding protein-like protein A; Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits. | 0.925 |
| nanA | iga | spr1536 | spr1042 | Sialidase A precursor (neuraminidase A); Belongs to the glycosyl hydrolase 33 family. | Immunoglobulin A1 protease; Zinc metalloproteinase which cleaves human immunoglobulin A1 (IgA1) in the hinge region. | 0.834 |
| nanA | phtA | spr1536 | spr1061 | Sialidase A precursor (neuraminidase A); Belongs to the glycosyl hydrolase 33 family. | Pneumococcal histidine triad protein A precursor. | 0.429 |
| nanA | phtD | spr1536 | spr0907 | Sialidase A precursor (neuraminidase A); Belongs to the glycosyl hydrolase 33 family. | Pneumococcal histidine triad protein D precursor. | 0.599 |
| nanA | phtE | spr1536 | spr0908 | Sialidase A precursor (neuraminidase A); Belongs to the glycosyl hydrolase 33 family. | Pneumococcal histidine triad protein E precursor. | 0.599 |
STRING v12.5 is now available!
