Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
hk06Histidine kinase. (443 aa)    
Predicted Functional Partners:
rr06
Response regulator.
 
 
 
 0.997
acoL
Dihydrolipoamide dehydrogenase.
    
 0.934
vncR
VncR, response regulator.
 
 
 
 0.900
vex3
ABC transporter membrane-spanning permease - Pep export.
 
 
 
 0.831
vex2
ABC transporter ATP-binding protein - Pep export.
 
 
 0.830
vex1
ABC transporter membrane-spanning permease - Pep export.
 
 
 
 0.815
rr08
Response regulator.
 
 
 0.744
rr01
Response regulator.
 
 
 
 0.711
phoP
Response regulator.
 
 
 
 0.681
pppL
Phosphoprotein phosphatase; Protein phosphatase able to dephosphorylate StkP-P and other phosphorylated protein substrates. PhpP and its cognate protein kinase StkP appear to constitute a functional signaling couple in vivo, PhpP's primary role being probably to control phosphorylation levels of StkP and of its targets. PhpP thus performs an essential control of StkP activity (By similarity); Belongs to the PP2C family.
   
 
 0.662
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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