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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hk06Histidine kinase. (443 aa)    
Predicted Functional Partners:
rr06
Response regulator.
 
 0.999
acoL
Dihydrolipoamide dehydrogenase.
    
 0.971
vncR
VncR, response regulator.
 
 0.931
rr08
Response regulator.
 
 
 0.813
rr01
Response regulator.
 
 
 0.809
vex3
ABC transporter membrane-spanning permease - Pep export.
 
  
 0.795
vex1
ABC transporter membrane-spanning permease - Pep export.
 
  
 0.787
phoP
Response regulator.
 
 0.783
vex2
ABC transporter ATP-binding protein - Pep export.
 
  
 0.774
ciaR
Response regulator, transcriptional regulatory protein; Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility.
 
 0.749
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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