Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
rr06Response regulator. (217 aa)    
Predicted Functional Partners:
hk06
Histidine kinase.
 
 
 
 0.997
spr1996
Conserved hypothetical protein.
     
 0.951
rr09
Response regulator.
  
   
 0.947
hk08
Histidine kinase.
 
 
 0.940
vncS
VncS, histidine kinase.
 
 
 0.903
hk01
Histidine kinase.
 
 
 0.843
hk02
Histidine kinase.
 
 
 0.812
phoR
Histidine kinase.
 
 
 0.799
ciaH
Sensor protein CiaH histide kinase; Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility. Probably phosphorylates CiaR.
 
 
 
 0.749
rr03
Response regulator.
  
 
 0.725
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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