Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
spr2005Conserved hypothetical protein. (96 aa)    
Predicted Functional Partners:
ABC-MSP-21
ABC transporter membrane-spanning permease - unknown substrate.
 
    0.963
spr2003
Conserved hypothetical protein.
 
    0.945
ABC-NBD-30
ABC transporter ATP-binding protein - anion transport.
 
    0.933
spr2000
Class III stress response-related ATPase, truncation; Belongs to the ClpA/ClpB family.
       0.547
ctsR
Transcriptional regulator CtsR; Belongs to the CtsR family.
       0.547
spr1999
Class III stress response-related ATPase, truncation.
       0.521
cbpD
Choline binding protein D.
       0.420
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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