Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
comFAInvolved in transformation; required for DNA uptake but not for binding; Related to ATP-dependent RNA/DNA helicases. (432 aa)    
Predicted Functional Partners:
comFC
Involved in transformation (competence for DNA uptake).
 
  
 0.996
smf
DNA processing Smf protein; Protein that helps load RecA onto ssDNA during transformation. Required for DNA transformation. Not required for DNA uptake but for a later stage of transformation. Thought to interact at the cell pole with newly imported transforming ssDNA which it binds cooperatively, protecting linear and circular ssDNA from nuclease action. Forms bridges between DNA segments. Favors the loading of RecA onto ssDNA and formation of RecA-DNA filaments, triggering RecA- catalysis of ATP-driven homologous DNA pairing. Belongs to the DprA/Smf family.
   
  
 0.970
ssbB
Single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
   
  
 0.952
endA
DNA-entry nuclease (competence-specific nuclease); By degrading DNA that enters the cell, plays a role in the competence of cells to be transformed; Belongs to the DNA/RNA non-specific endonuclease family.
      
 0.940
cglA
Competence induced; comG-like protein A; Also known as cilD.
   
  
 0.935
recA
DNA recombination/repair; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs (By similarity). It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity). Required for DNA transformation; protects transforming DNA from degradation, possibly in combination with DprA. Present at 15,000-30,000 monomers per competent cell.
      
 0.922
cglC
Competence induced; comG-like protein C.
 
  
 0.883
comE
Response regulator; Required for induction of competence.
      
 0.883
spr2014
Conserved hypothetical protein.
     
 0.875
coiA
Competence induced protein A.
  
  
 0.863
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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