Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
spr2014Conserved hypothetical protein. (211 aa)    
Predicted Functional Partners:
hpf
Conserved hypothetical protein; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
     
 0.953
spr1259
Conserved hypothetical protein.
   
  
 0.897
ABC-NBD-5
ABC transporter ATP-binding protein - unknown substrate.
     
 0.894
ABC-MSP-6
ABC transporter membrane-spanning permease - unknown substrate.
      
 0.893
spr1260
Conserved hypothetical protein; Similar to E. coli extragenic suppressor protein SuhB.
      
 0.886
spr0777
Conserved hypothetical protein; Putative permease.
     
 0.883
spr1357
Conserved hypothetical protein; Putative membrane protein.
     
 0.883
comFA
Involved in transformation; required for DNA uptake but not for binding; Related to ATP-dependent RNA/DNA helicases.
     
 0.875
comFC
Involved in transformation (competence for DNA uptake).
       0.709
cycK
Cysteine synthase, O-acetylserine sulfhydrylase; Belongs to the cysteine synthase/cystathionine beta- synthase family.
   
   0.688
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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