node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABC-MSP | comC | spr0081 | spr2043 | ABC transporter membrane-spanning permease - sugar transport. | Competence stimulating peptide precursor (CSP); Acts as a pheromone, induces cells to develop competence for genetic transformation; Belongs to the ComC family. | 0.600 |
cbpD | comC | spr2006 | spr2043 | Choline binding protein D. | Competence stimulating peptide precursor (CSP); Acts as a pheromone, induces cells to develop competence for genetic transformation; Belongs to the ComC family. | 0.723 |
cbpD | comD | spr2006 | spr2042 | Choline binding protein D. | Histidine protein kinase; Required for induction of competence. | 0.810 |
cbpD | comE | spr2006 | spr2041 | Choline binding protein D. | Response regulator; Required for induction of competence. | 0.851 |
cbpD | luxS | spr2006 | spr0308 | Choline binding protein D. | Autoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) (By similarity); Belongs to the LuxS family. | 0.698 |
cbpD | ply | spr2006 | spr1739 | Choline binding protein D. | Pneumolysin (sulfhydryl-activated toxin that lyses cholesterol containing membranes); Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity). | 0.807 |
cbpD | smf | spr2006 | spr1144 | Choline binding protein D. | DNA processing Smf protein; Protein that helps load RecA onto ssDNA during transformation. Required for DNA transformation. Not required for DNA uptake but for a later stage of transformation. Thought to interact at the cell pole with newly imported transforming ssDNA which it binds cooperatively, protecting linear and circular ssDNA from nuclease action. Forms bridges between DNA segments. Favors the loading of RecA onto ssDNA and formation of RecA-DNA filaments, triggering RecA- catalysis of ATP-driven homologous DNA pairing. Belongs to the DprA/Smf family. | 0.649 |
cbpD | ssbB | spr2006 | spr1724 | Choline binding protein D. | Single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. | 0.466 |
comB | comC | spr0044 | spr2043 | Transport protein ComB; Required for induction of competence; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Competence stimulating peptide precursor (CSP); Acts as a pheromone, induces cells to develop competence for genetic transformation; Belongs to the ComC family. | 0.634 |
comB | comD | spr0044 | spr2042 | Transport protein ComB; Required for induction of competence; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Histidine protein kinase; Required for induction of competence. | 0.772 |
comB | comE | spr0044 | spr2041 | Transport protein ComB; Required for induction of competence; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Response regulator; Required for induction of competence. | 0.850 |
comB | smf | spr0044 | spr1144 | Transport protein ComB; Required for induction of competence; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | DNA processing Smf protein; Protein that helps load RecA onto ssDNA during transformation. Required for DNA transformation. Not required for DNA uptake but for a later stage of transformation. Thought to interact at the cell pole with newly imported transforming ssDNA which it binds cooperatively, protecting linear and circular ssDNA from nuclease action. Forms bridges between DNA segments. Favors the loading of RecA onto ssDNA and formation of RecA-DNA filaments, triggering RecA- catalysis of ATP-driven homologous DNA pairing. Belongs to the DprA/Smf family. | 0.415 |
comC | ABC-MSP | spr2043 | spr0081 | Competence stimulating peptide precursor (CSP); Acts as a pheromone, induces cells to develop competence for genetic transformation; Belongs to the ComC family. | ABC transporter membrane-spanning permease - sugar transport. | 0.600 |
comC | cbpD | spr2043 | spr2006 | Competence stimulating peptide precursor (CSP); Acts as a pheromone, induces cells to develop competence for genetic transformation; Belongs to the ComC family. | Choline binding protein D. | 0.723 |
comC | comB | spr2043 | spr0044 | Competence stimulating peptide precursor (CSP); Acts as a pheromone, induces cells to develop competence for genetic transformation; Belongs to the ComC family. | Transport protein ComB; Required for induction of competence; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.634 |
comC | comD | spr2043 | spr2042 | Competence stimulating peptide precursor (CSP); Acts as a pheromone, induces cells to develop competence for genetic transformation; Belongs to the ComC family. | Histidine protein kinase; Required for induction of competence. | 0.999 |
comC | comE | spr2043 | spr2041 | Competence stimulating peptide precursor (CSP); Acts as a pheromone, induces cells to develop competence for genetic transformation; Belongs to the ComC family. | Response regulator; Required for induction of competence. | 0.985 |
comC | luxS | spr2043 | spr0308 | Competence stimulating peptide precursor (CSP); Acts as a pheromone, induces cells to develop competence for genetic transformation; Belongs to the ComC family. | Autoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) (By similarity); Belongs to the LuxS family. | 0.720 |
comC | ply | spr2043 | spr1739 | Competence stimulating peptide precursor (CSP); Acts as a pheromone, induces cells to develop competence for genetic transformation; Belongs to the ComC family. | Pneumolysin (sulfhydryl-activated toxin that lyses cholesterol containing membranes); Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity). | 0.724 |
comC | rpsL | spr2043 | spr0248 | Competence stimulating peptide precursor (CSP); Acts as a pheromone, induces cells to develop competence for genetic transformation; Belongs to the ComC family. | 30S Ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. | 0.731 |