EQW78_09705 protein (Oerskovia turbata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

EQW78_09705

Unannotated protein. (336 aa)

Predicted Functional Partners:

EQW78_02410

0.776

EQW78_04650

0.759

EQW78_01920

0.749

EQW78_14835

0.656

EQW78_03835

0.616

EQW78_09710

0.610

EQW78_02805

0.524

GCA_000718325_00543

0.477

EQW78_14275

0.477

EQW78_16870

0.461

Your Current Organism:

Oerskovia turbata

NCBI taxonomy Id: 1713
Other names: ATCC 25835, CFBP 4266, CIP 100331, Cellulomonas turbata, Cellulosimonas turbata, DSM 20577, IFO 13506, IFO 15015, JCM 3160, LMG 4072, LMG:4072, NBRC 15015, NCIB 10587, NCIB:10587, NCIMB 10587, NCTC 11973, NRRL B-8019, Nocardia turbata, O. turbata, strain 891, strain rskov 27

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EQW78_01920	EQW78_02410	GCA_000718325_00034	GCA_000718325_00136	Unannotated protein.	Unannotated protein.	0.711
EQW78_01920	EQW78_02805	GCA_000718325_00034	GCA_000718325_00213	Unannotated protein.	Unannotated protein; Belongs to the ATP-dependent AMP-binding enzyme family.	0.524
EQW78_01920	EQW78_04650	GCA_000718325_00034	GCA_000718325_01439	Unannotated protein.	Unannotated protein.	0.714
EQW78_01920	EQW78_09705	GCA_000718325_00034	GCA_000718325_00854	Unannotated protein.	Unannotated protein.	0.749
EQW78_01920	EQW78_14275	GCA_000718325_00034	GCA_000718325_03238	Unannotated protein.	Unannotated protein.	0.546
EQW78_01920	EQW78_16870	GCA_000718325_00034	GCA_000718325_01108	Unannotated protein.	Unannotated protein.	0.461
EQW78_01920	GCA_000718325_00543	GCA_000718325_00034	GCA_000718325_00543	Unannotated protein.	Unannotated protein.	0.538
EQW78_02410	EQW78_01920	GCA_000718325_00136	GCA_000718325_00034	Unannotated protein.	Unannotated protein.	0.711
EQW78_02410	EQW78_03835	GCA_000718325_00136	GCA_000718325_01276	Unannotated protein.	Unannotated protein.	0.747
EQW78_02410	EQW78_04650	GCA_000718325_00136	GCA_000718325_01439	Unannotated protein.	Unannotated protein.	0.978
EQW78_02410	EQW78_09705	GCA_000718325_00136	GCA_000718325_00854	Unannotated protein.	Unannotated protein.	0.776
EQW78_02410	EQW78_14835	GCA_000718325_00136	GCA_000718325_02393	Unannotated protein.	Unannotated protein.	0.612
EQW78_02805	EQW78_01920	GCA_000718325_00213	GCA_000718325_00034	Unannotated protein; Belongs to the ATP-dependent AMP-binding enzyme family.	Unannotated protein.	0.524
EQW78_02805	EQW78_03835	GCA_000718325_00213	GCA_000718325_01276	Unannotated protein; Belongs to the ATP-dependent AMP-binding enzyme family.	Unannotated protein.	0.524
EQW78_02805	EQW78_09705	GCA_000718325_00213	GCA_000718325_00854	Unannotated protein; Belongs to the ATP-dependent AMP-binding enzyme family.	Unannotated protein.	0.524
EQW78_02805	EQW78_14835	GCA_000718325_00213	GCA_000718325_02393	Unannotated protein; Belongs to the ATP-dependent AMP-binding enzyme family.	Unannotated protein.	0.524
EQW78_03835	EQW78_02410	GCA_000718325_01276	GCA_000718325_00136	Unannotated protein.	Unannotated protein.	0.747
EQW78_03835	EQW78_02805	GCA_000718325_01276	GCA_000718325_00213	Unannotated protein.	Unannotated protein; Belongs to the ATP-dependent AMP-binding enzyme family.	0.524
EQW78_03835	EQW78_04650	GCA_000718325_01276	GCA_000718325_01439	Unannotated protein.	Unannotated protein.	0.669
EQW78_03835	EQW78_09705	GCA_000718325_01276	GCA_000718325_00854	Unannotated protein.	Unannotated protein.	0.616

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Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

54

PPI enrichment p-value:

0.179

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006633

Fatty acid biosynthetic process

4 of 29

1.79

1.52

0.00065

GO:0016053

Organic acid biosynthetic process

5 of 152

1.17

0.88

0.0037

GO:0044249

Cellular biosynthetic process

8 of 762

0.68

0.48

0.0072

GO:1901576

Organic substance biosynthetic process

8 of 797

0.66

0.47

0.0072

GO:0044237

Cellular metabolic process

11 of 1801

0.44

0.35

0.0037

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031177

Phosphopantetheine binding

2 of 4

2.35

0.81

0.0334

GO:0000036

Acyl carrier activity

2 of 3

2.48

0.81

0.0334

GO:0004315

3-oxoacyl-[acyl-carrier-protein] synthase activity

2 of 9

2.0

0.79

0.0334

GO:0016746

Acyltransferase activity

3 of 80

1.23

0.59

0.0460

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:923

Phosphopantetheine, and 4-phosphopantetheinyl transferase domain

8 of 19

2.28

6.47

3.31e-15

CL:914

Fatty acid biosynthetic process, and Condensation domain

10 of 40

2.05

6.18

4.55e-17

CL:926

Polyketide synthase, phosphopantetheine-binding domain, and 4-phosphopantetheinyl transferase domain

6 of 14

2.29

4.89

5.10e-11

CL:928

Nonribosomal peptide structures, and Polyketide synthase dehydratase

5 of 8

2.45

4.49

1.33e-09

CL:901

Mixed, incl. Monocarboxylic acid biosynthetic process, and Short-chain dehydrogenase/reductase SDR

11 of 101

1.69

4.29

1.57e-16

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01054

Nonribosomal peptide structures

7 of 9

2.55

6.69

3.20e-14

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005835

Fatty acid synthase complex

7 of 13

2.39

5.89

5.00e-13

GOCC:0032991

Protein-containing complex

8 of 600

0.78

0.66

0.00049

GOCC:0005737

Cytoplasm

10 of 968

0.67

0.58

0.00011

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0596

Phosphopantetheine

7 of 13

2.39

5.93

3.93e-13

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00550

Phosphopantetheine attachment site

8 of 15

2.38

6.65

5.90e-15

PF00501

AMP-binding enzyme

6 of 13

2.32

4.7

2.01e-10

PF00668

Condensation domain

5 of 7

2.51

4.36

3.25e-09

PF13193

AMP-binding enzyme C-terminal domain

3 of 8

2.23

1.91

0.00022

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036736

ACP-like superfamily

9 of 16

2.4

7.56

3.75e-17

IPR009081

Phosphopantetheine binding ACP domain

8 of 15

2.38

6.61

7.43e-15

IPR020806

Polyketide synthase, phosphopantetheine-binding domain

6 of 11

2.39

4.84

1.54e-10

IPR000873

AMP-dependent synthetase/ligase domain

6 of 13

2.32

4.65

2.53e-10

IPR010071

Amino acid adenylation domain

5 of 7

2.51

4.28

4.91e-09

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00822

This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.

2 of 3

2.48

1.2

0.0062

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