STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
UvrBThe UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; Derived by automated computational analysis using gene prediction method: Protein Homology. (670 aa)    
Predicted Functional Partners:
UvrA
Excinuclease ABC subunit A; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.999
uvrC
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; Derived by automated computational analysis using gene prediction method: Protein Homology.
 0.999
MutL
DNA mismatch repair protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.902
KPL46456.1
DNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.841
KPL45402.1
N-6 DNA methylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.841
KPL46319.1
Double-stranded DNA repair protein Mre11; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.643
KPL45424.1
ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.616
TrxB
Thioredoxin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.614
dnaK
Molecular chaperone DnaK; Heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.591
Fen
Endonuclease; FEN-1; Rad2; similar to eukaryotic enzymes; endonuclease that cleave the 5'overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'end of a downstream Okazaki fragment; as 5'endo-/exonuclease and 5'pseudo-Y-endonuclease activities; cleaves the junction between single and double-stranded regions of flap DNA; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.588
Your Current Organism:
Methanosarcina flavescens
NCBI taxonomy Id: 1715806
Other names: DSM 100822, JCM 30921, M. flavescens, Methanosarcina flavescens Kern et al. 2016, Methanosarcina sp. E03.2, strain E03.2
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