STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MerMethylene-tetrahydromethanopterin reductase; Catalyzes the reduction of methylenetetrahydromethanopterin to methyltetrahydromethanopterin with the oxidation of coenzyme F420; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)    
Predicted Functional Partners:
KPL44981.1
Methylenetetrahydromethanopterin dehydrogenase; Catalyzes the reduction of methenyl-tetrahydromethanopterin to methylene-tetrahydromethanopterin; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.981
CdhC
acetyl-CoA decarbonylase/synthase complex subunit beta; In acetogenic organisms, this enzyme complex converts carbon dioxide to acetyl-CoA while in methanogenic organisms this enzyme is used to degrade acetyl-CoA to form methane and carbon dioxide; part of an enzyme complex; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.979
MtrA
Catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin; involved in methanogenesis from carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.977
FrhB
Coenzyme F420-reducing hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.955
MtrH
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of mtrA; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.948
MtrH-2
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of mtrA; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.945
KPL45129.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.945
FrhG
Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.941
FrhD
Coenzyme F420 hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.922
KPL46560.1
Tetrahydromethanopterin S-methyltransferase subunit E; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.919
Your Current Organism:
Methanosarcina flavescens
NCBI taxonomy Id: 1715806
Other names: DSM 100822, JCM 30921, M. flavescens, Methanosarcina flavescens Kern et al. 2016, Methanosarcina sp. E03.2, strain E03.2
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