KPL45317.1 protein (Methanosarcina flavescens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

KPL45317.1

Chromosome segregation ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (336 aa)

Predicted Functional Partners:

PstA

0.571

KPL45316.1

0.482

KPL45318.1

0.458

KPL46058.1

0.426

KPL46079.1

0.426

Your Current Organism:

Methanosarcina flavescens

NCBI taxonomy Id: 1715806
Other names: DSM 100822, JCM 30921, M. flavescens, Methanosarcina flavescens Kern et al. 2016, Methanosarcina sp. E03.2, strain E03.2

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KPL45316.1	KPL45317.1	AOB57_09455	AOB57_09460	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Chromosome segregation ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.482
KPL45317.1	KPL45316.1	AOB57_09460	AOB57_09455	Chromosome segregation ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.482
KPL45317.1	KPL45318.1	AOB57_09460	AOB57_09465	Chromosome segregation ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.458
KPL45317.1	KPL46058.1	AOB57_09460	AOB57_07350	Chromosome segregation ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.426
KPL45317.1	KPL46079.1	AOB57_09460	AOB57_07355	Chromosome segregation ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.426
KPL45317.1	PstA	AOB57_09460	AOB57_04825	Chromosome segregation ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.571
KPL45318.1	KPL45317.1	AOB57_09465	AOB57_09460	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Chromosome segregation ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.458
KPL46058.1	KPL45317.1	AOB57_07350	AOB57_09460	NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Chromosome segregation ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.426
KPL46058.1	KPL46079.1	AOB57_07350	AOB57_07355	NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
KPL46058.1	PstA	AOB57_07350	AOB57_04825	NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.590
KPL46079.1	KPL45317.1	AOB57_07355	AOB57_09460	Dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Chromosome segregation ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.426
KPL46079.1	KPL46058.1	AOB57_07355	AOB57_07350	Dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
KPL46079.1	PstA	AOB57_07355	AOB57_04825	Dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.590
PstA	KPL45317.1	AOB57_04825	AOB57_09460	Phosphate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Chromosome segregation ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.571
PstA	KPL46058.1	AOB57_04825	AOB57_07350	Phosphate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.590
PstA	KPL46079.1	AOB57_04825	AOB57_07355	Phosphate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.590

Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.659

expected number of edges:

11

PPI enrichment p-value:

4.68e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032259

Methylation

9 of 129

1.43

2.38

1.51e-09

GO:0009234

Menaquinone biosynthetic process

2 of 4

2.29

0.83

0.0299

GO:0008152

Metabolic process

11 of 1593

0.43

0.32

0.0100

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008168

Methyltransferase activity

9 of 92

1.58

3.06

4.10e-11

GO:0016740

Transferase activity

10 of 431

0.95

1.09

2.00e-07

GO:0003824

Catalytic activity

11 of 1535

0.44

0.36

0.0016

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043231

Intracellular membrane-bounded organelle

4 of 164

0.98

0.57

0.0276

GO:0016020

Membrane

7 of 595

0.66

0.42

0.0221

GO:0016021

Integral component of membrane

6 of 481

0.69

0.42

0.0276

GO:0110165

Cellular anatomical entity

11 of 1922

0.35

0.27

0.0221

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3564

Ubiquinone and other terpenoid-quinone biosynthesis, and Methyltransferase domain

8 of 37

1.92

4.3

9.55e-12

CL:3569

Ubiquinone and other terpenoid-quinone biosynthesis, and O-methyltransferase domain

6 of 18

2.11

4.11

9.13e-10

CL:3566

Mixed, incl. Methyltransferase domain 25, and NADPH-dependent FMN reductase-like

7 of 30

1.96

4.07

1.22e-10

CL:3589

Menaquinone metabolic process, and Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

4 of 5

2.49

3.42

2.82e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00130

Ubiquinone and other terpenoid-quinone biosynthesis

9 of 46

1.88

4.77

2.83e-14

map01110

Biosynthesis of secondary metabolites

9 of 436

0.9

0.94

3.26e-06

map01100

Metabolic pathways

9 of 1101

0.5

0.38

0.0061

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0110165

Cellular anatomical entity

11 of 1364

0.5

0.41

0.00089

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13489

Methyltransferase domain

3 of 10

2.07

1.43

0.0017

PF05401

Nodulation protein S (NodS)

2 of 6

2.11

0.75

0.0398

PF01209

ubiE/COQ5 methyltransferase family

2 of 8

1.99

0.73

0.0425

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029063

S-adenosyl-L-methionine-dependent methyltransferase superfamily

9 of 97

1.56

2.89

1.52e-10

IPR013216

Methyltransferase type 11

4 of 25

1.79

1.65

0.00031

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (14%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About