STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HisDHistidinol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (433 aa)    
Predicted Functional Partners:
hisH
Imidazole glycerol phosphate synthase subunit HisH; With HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; Derived by automated computational analysis using gene prediction meth [...]
  
 0.999
HisB
Imidazoleglycerol-phosphate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.999
KPL46574.1
ATP phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.999
HisF
Imidazole glycerol phosphate synthase subunit HisF; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.999
HisI
phosphoribosyl-AMP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.998
KPL46632.1
1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.998
HisE
phosphoribosyl-ATP pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.994
KPL45854.1
Histidinol-phosphate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.986
MutS
DNA mismatch repair protein MutS; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.934
Fen
Endonuclease; FEN-1; Rad2; similar to eukaryotic enzymes; endonuclease that cleave the 5'overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'end of a downstream Okazaki fragment; as 5'endo-/exonuclease and 5'pseudo-Y-endonuclease activities; cleaves the junction between single and double-stranded regions of flap DNA; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.879
Your Current Organism:
Methanosarcina flavescens
NCBI taxonomy Id: 1715806
Other names: DSM 100822, JCM 30921, M. flavescens, Methanosarcina flavescens Kern et al. 2016, Methanosarcina sp. E03.2, strain E03.2
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