STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ccmCHeme transporter HemC; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family. (239 aa)    
Predicted Functional Partners:
KIC60957.1
Heme exporter protein B; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family.
 
 
 0.998
ccmE
Cytochrome C biogenesis protein CcmE; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family.
 
 
 0.992
KIC60749.1
Hemagglutination activity protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmD/CycX/HelD family.
  
 
 0.986
KIC60748.1
Thiol:disulfide interchange protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.983
ccmA
Cytochrome C biogenesis protein CcmA; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
 
 
 0.975
KIC59226.1
Cytochrome C biogenesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.943
KIC60393.1
Cytochrome c-type biogenesis protein; required for the transfer of heme to apocytochrome c; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.893
KIC60394.1
Cytochrome C biogenesis protein; Possible subunit of a heme lyase.
 
  
 0.873
KIC56765.1
uroporphyrin-III methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
  
  
 0.646
KIC60747.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.631
Your Current Organism:
Brevundimonas nasdae
NCBI taxonomy Id: 172043
Other names: B. nasdae, Brevundimonas nasdae Li et al. 2004, DSM 14572, JCM 11415, strain W1-2B
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