| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KIC56890.1 | KIC60574.1 | RM53_11035 | RM53_03775 | Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | L-aspartate oxidase; Catalyzes the formation of oxaloacetate from L-aspartate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.905 |
| KIC56890.1 | KIC60575.1 | RM53_11035 | RM53_03780 | Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | Nicotinate-nucleotide pyrophosphorylase; Catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NadC/ModD family. | 0.443 |
| KIC56890.1 | KIC61047.1 | RM53_11035 | RM53_00225 | Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | Aspartate aminotransferase; Catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.907 |
| KIC56890.1 | gltA | RM53_11035 | RM53_13180 | Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | Type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. | 0.969 |
| KIC56890.1 | mdh | RM53_11035 | RM53_01350 | Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.924 |
| KIC58587.1 | KIC60574.1 | RM53_07940 | RM53_03775 | Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. | L-aspartate oxidase; Catalyzes the formation of oxaloacetate from L-aspartate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.894 |
| KIC58587.1 | KIC61047.1 | RM53_07940 | RM53_00225 | Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. | Aspartate aminotransferase; Catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.952 |
| KIC58587.1 | argG | RM53_07940 | RM53_10410 | Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. | Argininosuccinate synthase; Catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | 0.928 |
| KIC58587.1 | purA | RM53_07940 | RM53_04345 | Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.908 |
| KIC60574.1 | KIC56890.1 | RM53_03775 | RM53_11035 | L-aspartate oxidase; Catalyzes the formation of oxaloacetate from L-aspartate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.905 |
| KIC60574.1 | KIC58587.1 | RM53_03775 | RM53_07940 | L-aspartate oxidase; Catalyzes the formation of oxaloacetate from L-aspartate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. | 0.894 |
| KIC60574.1 | KIC60575.1 | RM53_03775 | RM53_03780 | L-aspartate oxidase; Catalyzes the formation of oxaloacetate from L-aspartate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Nicotinate-nucleotide pyrophosphorylase; Catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NadC/ModD family. | 0.999 |
| KIC60574.1 | KIC61047.1 | RM53_03775 | RM53_00225 | L-aspartate oxidase; Catalyzes the formation of oxaloacetate from L-aspartate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aspartate aminotransferase; Catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.901 |
| KIC60574.1 | argG | RM53_03775 | RM53_10410 | L-aspartate oxidase; Catalyzes the formation of oxaloacetate from L-aspartate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Argininosuccinate synthase; Catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | 0.906 |
| KIC60574.1 | gltA | RM53_03775 | RM53_13180 | L-aspartate oxidase; Catalyzes the formation of oxaloacetate from L-aspartate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. | 0.907 |
| KIC60574.1 | mdh | RM53_03775 | RM53_01350 | L-aspartate oxidase; Catalyzes the formation of oxaloacetate from L-aspartate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.912 |
| KIC60574.1 | nadA | RM53_03775 | RM53_03765 | L-aspartate oxidase; Catalyzes the formation of oxaloacetate from L-aspartate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | 0.999 |
| KIC60574.1 | panD | RM53_03775 | RM53_11250 | L-aspartate oxidase; Catalyzes the formation of oxaloacetate from L-aspartate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aspartate decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | 0.914 |
| KIC60574.1 | purA | RM53_03775 | RM53_04345 | L-aspartate oxidase; Catalyzes the formation of oxaloacetate from L-aspartate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.908 |
| KIC60575.1 | KIC56890.1 | RM53_03780 | RM53_11035 | Nicotinate-nucleotide pyrophosphorylase; Catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NadC/ModD family. | Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.443 |
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