Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
KIC59724.1Alpha/beta hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the AB hydrolase superfamily. MetX family. (350 aa)    
Predicted Functional Partners:
KIC59725.1
Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.983
KIC59723.1
Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.967
KIC56063.1
Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.904
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.825
KIC60922.1
Threonine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.821
ilvA
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.821
trpB
Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
 0.800
trpA
Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
     
  0.800
KIC60680.1
Peptidyl-dipeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
    0.486
KIC58871.1
Oligoendopeptidase F; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
    0.486
Your Current Organism:
Brevundimonas nasdae
NCBI taxonomy Id: 172043
Other names: B. nasdae, Brevundimonas nasdae Li et al. 2004, DSM 14572, JCM 11415, strain W1-2B
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