| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KIC57165.1 | KIC57166.1 | RM53_10050 | RM53_10065 | Response regulator receiver protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 6-pyruvoyl tetrahydrobiopterin synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.512 |
| KIC57165.1 | queC | RM53_10050 | RM53_10055 | Response regulator receiver protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.528 |
| KIC57165.1 | queE | RM53_10050 | RM53_10060 | Response regulator receiver protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 7-cyano-7-deazaguanine reductase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.506 |
| KIC57165.1 | ribB | RM53_10050 | RM53_05750 | Response regulator receiver protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.792 |
| KIC57166.1 | KIC57165.1 | RM53_10065 | RM53_10050 | 6-pyruvoyl tetrahydrobiopterin synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Response regulator receiver protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.512 |
| KIC57166.1 | folE | RM53_10065 | RM53_06625 | 6-pyruvoyl tetrahydrobiopterin synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | GTP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.940 |
| KIC57166.1 | queC | RM53_10065 | RM53_10055 | 6-pyruvoyl tetrahydrobiopterin synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.990 |
| KIC57166.1 | queE | RM53_10065 | RM53_10060 | 6-pyruvoyl tetrahydrobiopterin synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 7-cyano-7-deazaguanine reductase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.998 |
| KIC57166.1 | queF | RM53_10065 | RM53_13420 | 6-pyruvoyl tetrahydrobiopterin synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.814 |
| KIC58993.1 | queC | RM53_07355 | RM53_10055 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.581 |
| cysC | glmS | RM53_09770 | RM53_00920 | Adenylyltransferase; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | 0.523 |
| cysC | queC | RM53_09770 | RM53_10055 | Adenylyltransferase; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.412 |
| cysC | queE | RM53_09770 | RM53_10060 | Adenylyltransferase; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 7-cyano-7-deazaguanine reductase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.441 |
| folE | KIC57166.1 | RM53_06625 | RM53_10065 | GTP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 6-pyruvoyl tetrahydrobiopterin synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.940 |
| folE | queC | RM53_06625 | RM53_10055 | GTP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.441 |
| folE | queE | RM53_06625 | RM53_10060 | GTP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 7-cyano-7-deazaguanine reductase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.544 |
| folE | ribB | RM53_06625 | RM53_05750 | GTP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.938 |
| glmS | cysC | RM53_00920 | RM53_09770 | Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | Adenylyltransferase; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.523 |
| glmS | murD | RM53_00920 | RM53_11305 | Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.414 |
| glmS | queC | RM53_00920 | RM53_10055 | Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.443 |