| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KIC56814.1 | KIC56816.1 | RM53_10615 | RM53_10625 | D,D-heptose 1,7-bisphosphate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the gmhB family. | Aminotransferase DegT; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DegT/DnrJ/EryC1 family. | 0.889 |
| KIC56814.1 | KIC60437.1 | RM53_10615 | RM53_02995 | D,D-heptose 1,7-bisphosphate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the gmhB family. | ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.905 |
| KIC56814.1 | KIC60716.1 | RM53_10615 | RM53_01020 | D,D-heptose 1,7-bisphosphate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the gmhB family. | GHMP kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.989 |
| KIC56814.1 | hisB | RM53_10615 | RM53_02880 | D,D-heptose 1,7-bisphosphate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the gmhB family. | Imidazoleglycerol-phosphate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.917 |
| KIC56814.1 | hisD | RM53_10615 | RM53_02885 | D,D-heptose 1,7-bisphosphate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the gmhB family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.899 |
| KIC56814.1 | hisF | RM53_10615 | RM53_02865 | D,D-heptose 1,7-bisphosphate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the gmhB family. | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.903 |
| KIC56814.1 | hisH | RM53_10615 | RM53_02875 | D,D-heptose 1,7-bisphosphate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the gmhB family. | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.921 |
| KIC56814.1 | hisI | RM53_10615 | RM53_02860 | D,D-heptose 1,7-bisphosphate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the gmhB family. | Imidazole glycerol phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; In the N-terminal section; belongs to the PRA-CH family. | 0.990 |
| KIC56814.1 | hldD | RM53_10615 | RM53_13350 | D,D-heptose 1,7-bisphosphate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the gmhB family. | ADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. | 0.947 |
| KIC56814.1 | hldE | RM53_10615 | RM53_13345 | D,D-heptose 1,7-bisphosphate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the gmhB family. | D-beta-D-heptose 1-phosphate adenosyltransferase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. | 0.979 |
| KIC56816.1 | KIC56814.1 | RM53_10625 | RM53_10615 | Aminotransferase DegT; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DegT/DnrJ/EryC1 family. | D,D-heptose 1,7-bisphosphate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the gmhB family. | 0.889 |
| KIC56816.1 | hldD | RM53_10625 | RM53_13350 | Aminotransferase DegT; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DegT/DnrJ/EryC1 family. | ADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. | 0.435 |
| KIC60437.1 | KIC56814.1 | RM53_02995 | RM53_10615 | ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. | D,D-heptose 1,7-bisphosphate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the gmhB family. | 0.905 |
| KIC60716.1 | KIC56814.1 | RM53_01020 | RM53_10615 | GHMP kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | D,D-heptose 1,7-bisphosphate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the gmhB family. | 0.989 |
| hisB | KIC56814.1 | RM53_02880 | RM53_10615 | Imidazoleglycerol-phosphate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. | D,D-heptose 1,7-bisphosphate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the gmhB family. | 0.917 |
| hisB | hisD | RM53_02880 | RM53_02885 | Imidazoleglycerol-phosphate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
| hisB | hisF | RM53_02880 | RM53_02865 | Imidazoleglycerol-phosphate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
| hisB | hisH | RM53_02880 | RM53_02875 | Imidazoleglycerol-phosphate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
| hisB | hisI | RM53_02880 | RM53_02860 | Imidazoleglycerol-phosphate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Imidazole glycerol phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
| hisD | KIC56814.1 | RM53_02885 | RM53_10615 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | D,D-heptose 1,7-bisphosphate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the gmhB family. | 0.899 |