| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KIC55938.1 | KIC55939.1 | RM53_13890 | RM53_13895 | Mechanosensitive ion channel protein MscS; Derived by automated computational analysis using gene prediction method: Protein Homology. | Threonine aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.782 |
| KIC55939.1 | KIC55938.1 | RM53_13895 | RM53_13890 | Threonine aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Mechanosensitive ion channel protein MscS; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.782 |
| KIC55939.1 | KIC56914.1 | RM53_13895 | RM53_11165 | Threonine aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pyridoxal-5'-phosphate-dependent protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.905 |
| KIC55939.1 | KIC58910.1 | RM53_13895 | RM53_06825 | Threonine aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glycine dehydrogenase; Acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.920 |
| KIC55939.1 | KIC59234.1 | RM53_13895 | RM53_05720 | Threonine aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Catalyzes the formation of 5-aminolevulinate from succinyl-CoA and glycine; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.906 |
| KIC55939.1 | KIC59838.1 | RM53_13895 | RM53_04725 | Threonine aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Threonine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.920 |
| KIC55939.1 | KIC60922.1 | RM53_13895 | RM53_02240 | Threonine aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Threonine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.920 |
| KIC55939.1 | gcvPA | RM53_13895 | RM53_06815 | Threonine aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.918 |
| KIC55939.1 | glyA | RM53_13895 | RM53_05730 | Threonine aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.929 |
| KIC55939.1 | ilvA | RM53_13895 | RM53_03760 | Threonine aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.905 |
| KIC55939.1 | kbl | RM53_13895 | RM53_07595 | Threonine aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2-amino-3-ketobutyrate CoA ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.906 |
| KIC56914.1 | KIC55939.1 | RM53_11165 | RM53_13895 | Pyridoxal-5'-phosphate-dependent protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Threonine aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.905 |
| KIC56914.1 | KIC59838.1 | RM53_11165 | RM53_04725 | Pyridoxal-5'-phosphate-dependent protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Threonine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.969 |
| KIC56914.1 | KIC60922.1 | RM53_11165 | RM53_02240 | Pyridoxal-5'-phosphate-dependent protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Threonine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.919 |
| KIC56914.1 | glyA | RM53_11165 | RM53_05730 | Pyridoxal-5'-phosphate-dependent protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.906 |
| KIC56914.1 | ilvA | RM53_11165 | RM53_03760 | Pyridoxal-5'-phosphate-dependent protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.917 |
| KIC58910.1 | KIC55939.1 | RM53_06825 | RM53_13895 | Glycine dehydrogenase; Acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Threonine aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.920 |
| KIC58910.1 | KIC59234.1 | RM53_06825 | RM53_05720 | Glycine dehydrogenase; Acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Catalyzes the formation of 5-aminolevulinate from succinyl-CoA and glycine; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.906 |
| KIC58910.1 | gcvPA | RM53_06825 | RM53_06815 | Glycine dehydrogenase; Acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.999 |
| KIC58910.1 | glyA | RM53_06825 | RM53_05730 | Glycine dehydrogenase; Acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.979 |
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