node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KKO77452.1 | KKO81933.1 | WU86_11460 | WU86_06410 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.776 |
KKO77452.1 | folP | WU86_11460 | WU86_06805 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydropteroate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.664 |
KKO77452.1 | thyA | WU86_11460 | WU86_11455 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
KKO81536.1 | KKO82153.1 | WU86_08865 | WU86_04795 | Anthranilate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 4-amino-4-deoxychorismate lyase; Catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.929 |
KKO81536.1 | folP | WU86_08865 | WU86_06805 | Anthranilate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydropteroate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.616 |
KKO81933.1 | KKO77452.1 | WU86_06410 | WU86_11460 | Dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.776 |
KKO81933.1 | folB | WU86_06410 | WU86_06810 | Dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.977 |
KKO81933.1 | folE | WU86_06410 | WU86_06800 | Dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | GTP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.977 |
KKO81933.1 | folP | WU86_06410 | WU86_06805 | Dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydropteroate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
KKO81933.1 | thyA | WU86_06410 | WU86_11455 | Dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.948 |
KKO82153.1 | KKO81536.1 | WU86_04795 | WU86_08865 | 4-amino-4-deoxychorismate lyase; Catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Anthranilate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.929 |
KKO82153.1 | folP | WU86_04795 | WU86_06805 | 4-amino-4-deoxychorismate lyase; Catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydropteroate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.921 |
folB | KKO81933.1 | WU86_06810 | WU86_06410 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.977 |
folB | folE | WU86_06810 | WU86_06800 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | GTP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
folB | folP | WU86_06810 | WU86_06805 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydropteroate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.998 |
folE | KKO81933.1 | WU86_06800 | WU86_06410 | GTP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.977 |
folE | folB | WU86_06800 | WU86_06810 | GTP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.999 |
folE | folP | WU86_06800 | WU86_06805 | GTP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydropteroate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
folP | KKO77452.1 | WU86_06805 | WU86_11460 | Dihydropteroate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.664 |
folP | KKO81536.1 | WU86_06805 | WU86_08865 | Dihydropteroate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Anthranilate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.616 |