KUO64729.1 protein (Gracilibacter sp. BRHc7a)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

KUO64729.1

DEAD/DEAH box helicase; Subunit R is required for both nuclease and ATPase activities, but not for modification. (969 aa)

Predicted Functional Partners:

KUO64784.1

0.983

KUO64727.1

0.983

KUO64728.1

0.977

KUO65810.1

0.966

KUO64726.1

0.941

KUO62225.1

0.928

KUO59702.1

0.918

KUO62226.1

0.903

KUO62222.1

0.884

KUO61240.1

0.833

Your Current Organism:

Gracilibacter sp. BRHc7a

NCBI taxonomy Id: 1734398
Other names: G. sp. BRH_c7a, Gracilibacter sp. BRH_c7a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KUO59702.1	KUO62225.1	APF84_13675	APF84_12835	SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.696
KUO59702.1	KUO62226.1	APF84_13675	APF84_12840	SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.865
KUO59702.1	KUO64726.1	APF84_13675	APF84_02495	SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.801
KUO59702.1	KUO64728.1	APF84_13675	APF84_02510	SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.969
KUO59702.1	KUO64729.1	APF84_13675	APF84_02515	SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DEAD/DEAH box helicase; Subunit R is required for both nuclease and ATPase activities, but not for modification.	0.918
KUO59702.1	KUO65810.1	APF84_13675	APF84_00710	SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.735
KUO61240.1	KUO62226.1	APF84_15910	APF84_12840	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.628
KUO61240.1	KUO64726.1	APF84_15910	APF84_02495	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.628
KUO61240.1	KUO64728.1	APF84_15910	APF84_02510	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.628
KUO61240.1	KUO64729.1	APF84_15910	APF84_02515	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	DEAD/DEAH box helicase; Subunit R is required for both nuclease and ATPase activities, but not for modification.	0.833
KUO62222.1	KUO62225.1	APF84_12820	APF84_12835	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.945
KUO62222.1	KUO62226.1	APF84_12820	APF84_12840	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.979
KUO62222.1	KUO64726.1	APF84_12820	APF84_02495	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.733
KUO62222.1	KUO64728.1	APF84_12820	APF84_02510	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.780
KUO62222.1	KUO64729.1	APF84_12820	APF84_02515	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	DEAD/DEAH box helicase; Subunit R is required for both nuclease and ATPase activities, but not for modification.	0.884
KUO62225.1	KUO59702.1	APF84_12835	APF84_13675	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.696
KUO62225.1	KUO62222.1	APF84_12835	APF84_12820	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.945
KUO62225.1	KUO62226.1	APF84_12835	APF84_12840	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.988
KUO62225.1	KUO64726.1	APF84_12835	APF84_02495	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.791
KUO62225.1	KUO64727.1	APF84_12835	APF84_02505	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.600

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Network Stats

number of nodes:

5

number of edges:

8

average node degree:

3.2

avg. local clustering coefficient:

0.867

expected number of edges:

4

PPI enrichment p-value:

0.0491

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009307

DNA restriction-modification system

2 of 4

2.51

1.17

0.0225

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009007

Site-specific DNA-methyltransferase (adenine-specific) activity

2 of 3

2.63

1.36

0.0121

GO:0008170

N-methyltransferase activity

2 of 10

2.11

1.08

0.0264

GO:0140097

Catalytic activity, acting on DNA

3 of 95

1.31

0.75

0.0407

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3112

Mixed, incl. DNA methylation on adenine, and Endodeoxyribonuclease activity, producing 5-phosphomonoesters

3 of 7

2.44

2.58

0.00016

CL:4245

Starch and sucrose metabolism

2 of 13

2.0

1.02

0.0306

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ntr00500

Starch and sucrose metabolism

2 of 17

1.88

0.97

0.0343

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01555

DNA methylase

2 of 4

2.51

1.3

0.0143

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002295

N4/N6-methyltransferase, Type III restriction-modification enzyme EcoPI Mod subunit-like

2 of 3

2.63

1.13

0.0263

IPR002941

DNA methylase N-4/N-6

2 of 4

2.51

1.12

0.0263

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