STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (804 aa)    
Predicted Functional Partners:
uvrB
Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
 
 0.994
uvrA
Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
 
 0.940
ALM11044.1
Hypothetical protein.
  
 
 0.893
ALM11297.1
DNA polymerase III subunit epsilon.
 
 
 0.813
pyrB
Aspartate carbamoyltransferase catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
    
 0.806
ALM11470.1
tRNA threonylcarbamoyladenosine biosynthesis protein; Belongs to the SUA5 family.
    
 0.786
ALM11455.1
Hypothetical protein.
    
  0.785
tsaD
O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family.
    
 0.763
ALM10824.1
DNA helicase II / ATP-dependent DNA helicase PcrA; Belongs to the helicase family. UvrD subfamily.
  
  
 0.721
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
    
 0.706
Your Current Organism:
Peribacter riflensis
NCBI taxonomy Id: 1735162
Other names: C. Peribacter riflensis, Candidatus Peregrinibacteria bacterium RIFOXYA2_FULL_PER-ii_58_14, Candidatus Peregrinibacteria bacterium RIFOXYB2_FULL_PER-ii_58_17, Candidatus Peregrinibacteria bacterium RIFOXYC2_FULL_PER-ii_58_32, Candidatus Peregrinibacteria bacterium RIFOXYD1_FULL_PER-ii_59_16, Candidatus Peregrinibacteria bacterium RIFOXYD2_FULL_PER-ii_51_23, Candidatus Peribacter riflensis, Candidatus Peribacteria bacterium RIFOXYA2_FULL_PER-ii_58_14, Candidatus Peribacteria bacterium RIFOXYB2_FULL_PER-ii_58_17, Candidatus Peribacteria bacterium RIFOXYC2_FULL_PER-ii_58_32, Candidatus Peribacteria bacterium RIFOXYD1_FULL_PER-ii_59_16, Candidatus Peribacteria bacterium RIFOXYD2_FULL_PER-ii_51_23
Server load: low (20%) [HD]