Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACH52_1000DNA polymerase III alpha subunit DnaE. (1138 aa)    
Predicted Functional Partners:
ACH52_0002
DNA polymerase III beta subunit DnaN; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiatio [...]
  
 
 0.990
ACH52_2815
DNA polymerase III delta subunit HolA.
  
 0.990
dnaX
DNA polymerase III subunit gamma and tau DnaX; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
 
 0.987
ACH52_3876
DNA polymerase III delta' subunit HolB.
 
 0.986
polC
DNA polymerase III alpha subunit Gram positive type PolC; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
    
0.918
ACH52_3081
3'-5' exonuclease.
    
 0.918
ACH52_3897
Single-stranded DNA-binding protein Ssb.
 
 
 
 0.873
ACH52_1734
Phage-related single-stranded DNA-binding protein.
 
 
 
 0.872
ACH52_1002
Pyruvate kinase Pyk; Belongs to the pyruvate kinase family.
  
  
 0.857
pfkA
6-phosphofructokinase PfkA; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
     
 0.822
Your Current Organism:
Eubacterium limosum
NCBI taxonomy Id: 1736
Other names: ATCC 8486, Bacteroides limosus, Butyribacterium limosum, Butyribacterium rettgeri, CCUG 16793, CIP 104169, DSM 20543, E. limosum, JCM 6421, JCM 9978, Mycobacterium limosum
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