STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACH52_1162Acetolactate synthase small subunit IlvN. (162 aa)    
Predicted Functional Partners:
ACH52_1161
Acetolactate synthase large subunit IlvB.
 0.999
ACH52_1320
Acetolactate synthase large subunit IlvB.
 0.999
ilvC
Ketol-acid reductoisomerase IlvC; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.997
ACH52_1993
Acetolactate synthase large subunit IlvB.
 
 0.993
leuB
3-isopropylmalate dehydrogenase LeuB; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 0.979
ACH52_1914
Threonine ammonia-lyase IlvA.
  
 
 0.978
ACH52_1315
2-isopropylmalate synthase LeuA; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 
 0.943
leuA
2-isopropylmalate synthase LeuA; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
 
 
 0.940
ACH52_3248
2-oxoacid:ferredoxin oxidoreductase alpha subunit.
  
 
 0.923
ACH52_2775
2-oxoacid:ferredoxin oxidoreductase alpha subunit.
  
 
 0.912
Your Current Organism:
Eubacterium limosum
NCBI taxonomy Id: 1736
Other names: ATCC 8486, Bacteroides limosus, Butyribacterium limosum, Butyribacterium rettgeri, CCUG 16793, CIP 104169, DSM 20543, E. limosum, JCM 6421, JCM 9978, Mycobacterium limosum
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