Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
addAHelicase-exonuclease AddA subunit; ATP-dependent DNA helicase. (1190 aa)    
Predicted Functional Partners:
ACH52_3210
Helicase-exonuclease AddB subunit; ATP-dependent DNA helicase.
 
 
 0.999
recD2
Helicase RecD/TraA family; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily.
  
 
 0.758
ACH52_1260
Relaxase/mobilization nuclease domain-containing protein.
  
 
 0.717
ACH52_3390
Relaxase/mobilization nuclease domain-containing protein.
  
 
 0.717
ACH52_2035
Hypothetical protein.
 
     0.709
ACH52_3118
ATP-dependent DNA helicase PcrA.
 
  
0.677
ACH52_3740
ATP-dependent DNA helicase UvrD/REP family.
 
  
0.629
sbcD
Exonuclease SbcD; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
 
  
 0.626
polA
DNA polymerase I PolA; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
     
 0.584
ruvA
Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
    
 0.554
Your Current Organism:
Eubacterium limosum
NCBI taxonomy Id: 1736
Other names: ATCC 8486, Bacteroides limosus, Butyribacterium limosum, Butyribacterium rettgeri, CCUG 16793, CIP 104169, DSM 20543, E. limosum, JCM 6421, JCM 9978, Mycobacterium limosum
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