| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KQZ62263.1 | KQZ64721.1 | ASD67_11950 | ASD67_09760 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 5,10-methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | 0.898 |
| KQZ62263.1 | KQZ64722.1 | ASD67_11950 | ASD67_09765 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.943 |
| KQZ62263.1 | KQZ64723.1 | ASD67_11950 | ASD67_09770 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.896 |
| KQZ62263.1 | metE | ASD67_11950 | ASD67_08050 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.846 |
| KQZ62263.1 | metK | ASD67_11950 | ASD67_04950 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.976 |
| KQZ64721.1 | KQZ62263.1 | ASD67_09760 | ASD67_11950 | 5,10-methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.898 |
| KQZ64721.1 | KQZ64722.1 | ASD67_09760 | ASD67_09765 | 5,10-methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.998 |
| KQZ64721.1 | KQZ64723.1 | ASD67_09760 | ASD67_09770 | 5,10-methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.996 |
| KQZ64721.1 | KQZ64995.1 | ASD67_09760 | ASD67_11405 | 5,10-methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.964 |
| KQZ64721.1 | KQZ65180.1 | ASD67_09760 | ASD67_09755 | 5,10-methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | ArsR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.892 |
| KQZ64721.1 | folD | ASD67_09760 | ASD67_01685 | 5,10-methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.930 |
| KQZ64721.1 | glyA | ASD67_09760 | ASD67_19410 | 5,10-methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.968 |
| KQZ64721.1 | metE | ASD67_09760 | ASD67_08050 | 5,10-methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.930 |
| KQZ64721.1 | metK | ASD67_09760 | ASD67_04950 | 5,10-methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.893 |
| KQZ64721.1 | thyA | ASD67_09760 | ASD67_21110 | 5,10-methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.920 |
| KQZ64722.1 | KQZ62263.1 | ASD67_09765 | ASD67_11950 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.943 |
| KQZ64722.1 | KQZ64721.1 | ASD67_09765 | ASD67_09760 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 5,10-methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | 0.998 |
| KQZ64722.1 | KQZ64723.1 | ASD67_09765 | ASD67_09770 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.999 |
| KQZ64722.1 | KQZ64995.1 | ASD67_09765 | ASD67_11405 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.954 |
| KQZ64722.1 | KQZ65180.1 | ASD67_09765 | ASD67_09755 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | ArsR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.886 |