OCC05504.1 protein (Labrys sp. WJW) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

Node Content

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

Experiments

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[Homology]

Score

OCC05504.1

TonB-dependent receptor; Derived by automated computational analysis using gene prediction method: Protein Homology. (726 aa)

Predicted Functional Partners:

OCC06385.1

0.864

OCC05557.1

0.829

OCC01194.1

0.771

OCC05191.1

0.738

OCC04894.1

0.738

OCC02931.1

0.738

OCC02119.1

0.738

OCC02361.1

0.722

OCC01195.1

0.719

OCC05489.1

0.707

Your Current Organism:

Labrys sp. WJW

NCBI taxonomy Id: 1737983
Other names: L. sp. WJW

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OCC01194.1	OCC01195.1	BA190_29890	BA190_29900	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Iron dicitrate transport regulator FecR; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.596
OCC01194.1	OCC04894.1	BA190_29890	BA190_10835	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.681
OCC01194.1	OCC05504.1	BA190_29890	BA190_08850	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	TonB-dependent receptor; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.771
OCC01195.1	OCC01194.1	BA190_29900	BA190_29890	Iron dicitrate transport regulator FecR; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.596
OCC01195.1	OCC05489.1	BA190_29900	BA190_08745	Iron dicitrate transport regulator FecR; Derived by automated computational analysis using gene prediction method: Protein Homology.	Iron dicitrate transport regulator FecR; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.481
OCC01195.1	OCC05504.1	BA190_29900	BA190_08850	Iron dicitrate transport regulator FecR; Derived by automated computational analysis using gene prediction method: Protein Homology.	TonB-dependent receptor; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.719
OCC02119.1	OCC04894.1	BA190_25340	BA190_10835	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.584
OCC02119.1	OCC05504.1	BA190_25340	BA190_08850	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	TonB-dependent receptor; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.738
OCC02361.1	OCC05489.1	BA190_23815	BA190_08745	Fe2+-dicitrate sensor protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Iron dicitrate transport regulator FecR; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.478
OCC02361.1	OCC05504.1	BA190_23815	BA190_08850	Fe2+-dicitrate sensor protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	TonB-dependent receptor; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.722
OCC02931.1	OCC05504.1	BA190_21090	BA190_08850	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	TonB-dependent receptor; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.738
OCC04894.1	OCC01194.1	BA190_10835	BA190_29890	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.681
OCC04894.1	OCC02119.1	BA190_10835	BA190_25340	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.584
OCC04894.1	OCC05504.1	BA190_10835	BA190_08850	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	TonB-dependent receptor; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.738
OCC05191.1	OCC05504.1	BA190_09790	BA190_08850	Protein TolA; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	TonB-dependent receptor; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.738
OCC05489.1	OCC01195.1	BA190_08745	BA190_29900	Iron dicitrate transport regulator FecR; Derived by automated computational analysis using gene prediction method: Protein Homology.	Iron dicitrate transport regulator FecR; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.481
OCC05489.1	OCC02361.1	BA190_08745	BA190_23815	Iron dicitrate transport regulator FecR; Derived by automated computational analysis using gene prediction method: Protein Homology.	Fe2+-dicitrate sensor protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.478
OCC05489.1	OCC05504.1	BA190_08745	BA190_08850	Iron dicitrate transport regulator FecR; Derived by automated computational analysis using gene prediction method: Protein Homology.	TonB-dependent receptor; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.707
OCC05504.1	OCC01194.1	BA190_08850	BA190_29890	TonB-dependent receptor; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.771
OCC05504.1	OCC01195.1	BA190_08850	BA190_29900	TonB-dependent receptor; Derived by automated computational analysis using gene prediction method: Protein Homology.	Iron dicitrate transport regulator FecR; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.719

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

28

PPI enrichment p-value:

1.83e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032784

Regulation of DNA-templated transcription, elongation

7 of 21

2.43

5.76

1.57e-12

GO:0032786

Positive regulation of DNA-templated transcription, elongation

6 of 19

2.41

4.81

2.09e-10

GO:0034243

Regulation of transcription elongation from RNA polymerase II promoter

3 of 14

2.24

2.06

0.00011

GO:0031401

Positive regulation of protein modification process

3 of 31

1.89

1.56

0.00070

GO:0010604

Positive regulation of macromolecule metabolic process

7 of 292

1.29

1.48

1.57e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016538

Cyclin-dependent protein serine/threonine kinase regulator activity

3 of 16

2.18

1.41

0.0021

GO:0061575

Cyclin-dependent protein serine/threonine kinase activator activity

2 of 3

2.73

1.08

0.0108

GO:0008353

RNA polymerase II CTD heptapeptide repeat kinase activity

2 of 5

2.51

1.08

0.0108

GO:0004693

Cyclin-dependent protein serine/threonine kinase activity

2 of 12

2.13

0.84

0.0278

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019908

Nuclear cyclin-dependent protein kinase holoenzyme complex

5 of 5

2.91

5.43

7.41e-11

GO:0000307

Cyclin-dependent protein kinase holoenzyme complex

6 of 18

2.43

5.03

7.41e-11

GO:0008023

Transcription elongation factor complex

6 of 19

2.41

5.0

7.41e-11

GO:0032806

Carboxy-terminal domain protein kinase complex

5 of 14

2.46

4.57

9.51e-10

GO:0008024

cyclin/CDK positive transcription elongation factor complex

4 of 4

2.91

4.44

6.10e-09

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1689

RNA Polymerase II Pre-transcription Events, and RNA polymerase core enzyme binding

10 of 80

2.0

5.86

1.17e-16

CL:1833

cyclin/CDK positive transcription elongation factor complex, and Glucose receptor Git3, N-terminal

5 of 7

2.76

5.08

2.52e-10

CL:1768

RNA Polymerase II Transcription Elongation

4 of 28

2.06

2.44

1.03e-05

CL:1690

RNA polymerase II, holoenzyme, and RNA polymerase core enzyme binding

5 of 71

1.76

2.27

4.73e-06

CL:1772

RNA polymerase II, core complex

3 of 11

2.34

2.13

9.09e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6796648

TP53 Regulates Transcription of DNA Repair Genes

9 of 40

2.26

6.92

1.08e-16

MAP-674695

RNA Polymerase II Pre-transcription Events

9 of 67

2.04

5.61

3.71e-15

MAP-75955

RNA Polymerase II Transcription Elongation

6 of 43

2.05

3.93

1.41e-09

MAP-6807505

RNA polymerase II transcribes snRNA genes

7 of 75

1.88

3.75

3.19e-10

MAP-113418

Formation of the Early Elongation Complex

5 of 32

2.1

3.43

4.92e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0008024

cyclin/CDK positive transcription elongation factor complex

5 of 6

2.83

5.24

1.46e-10

GOCC:0032806

Carboxy-terminal domain protein kinase complex

6 of 18

2.43

5.01

8.54e-11

GOCC:0008023

Transcription elongation factor complex

6 of 22

2.34

4.83

1.19e-10

GOCC:0061695

Transferase complex, transferring phosphorus-containing groups

8 of 150

1.63

3.08

3.11e-10

GOCC:0005654

Nucleoplasm

7 of 236

1.38

1.93

2.98e-07

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0195

Cyclin

2 of 7

2.36

1.05

0.0116

KW-0804

Transcription

3 of 109

1.35

0.67

0.0346

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00385

Domain present in cyclins, TFIIB and Retinoblastoma

2 of 10

2.21

0.84

0.0282

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