OCC01267.1 protein (Labrys sp. WJW) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

OCC01267.1

ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (262 aa)

Predicted Functional Partners:

OCC01268.1

0.999

OCC04438.1

0.983

OCC03972.1

0.983

OCC04888.1

0.972

OCC05601.1

0.970

OCC00718.1

0.951

OCC00461.1

0.938

OCC02152.1

0.916

OCC01308.1

0.913

OCC01266.1

0.902

Your Current Organism:

Labrys sp. WJW

NCBI taxonomy Id: 1737983
Other names: L. sp. WJW

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OCC00461.1	OCC01266.1	BA190_33935	BA190_29575	Branched-chain amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.907
OCC00461.1	OCC01267.1	BA190_33935	BA190_29580	Branched-chain amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.938
OCC00461.1	OCC01268.1	BA190_33935	BA190_29585	Branched-chain amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.609
OCC00461.1	OCC02152.1	BA190_33935	BA190_25150	Branched-chain amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Branched-chain amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.629
OCC00461.1	OCC04888.1	BA190_33935	BA190_10800	Branched-chain amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.503
OCC00718.1	OCC01266.1	BA190_32595	BA190_29575	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.812
OCC00718.1	OCC01267.1	BA190_32595	BA190_29580	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.951
OCC00718.1	OCC01268.1	BA190_32595	BA190_29585	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.595
OCC00718.1	OCC02152.1	BA190_32595	BA190_25150	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Branched-chain amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.609
OCC01266.1	OCC00461.1	BA190_29575	BA190_33935	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Branched-chain amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.907
OCC01266.1	OCC00718.1	BA190_29575	BA190_32595	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.812
OCC01266.1	OCC01267.1	BA190_29575	BA190_29580	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.902
OCC01266.1	OCC01268.1	BA190_29575	BA190_29585	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.990
OCC01266.1	OCC01308.1	BA190_29575	BA190_29590	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.903
OCC01266.1	OCC02152.1	BA190_29575	BA190_25150	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Branched-chain amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.914
OCC01266.1	OCC03972.1	BA190_29575	BA190_15890	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Branched-chain amino acid ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.965
OCC01266.1	OCC04438.1	BA190_29575	BA190_13605	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.929
OCC01266.1	OCC04888.1	BA190_29575	BA190_10800	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.982
OCC01266.1	OCC05601.1	BA190_29575	BA190_07495	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.890
OCC01267.1	OCC00461.1	BA190_29580	BA190_33935	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Branched-chain amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.938

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Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.816

expected number of edges:

11

PPI enrichment p-value:

8.64e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009067

Aspartate family amino acid biosynthetic process

8 of 31

1.91

4.28

7.25e-12

GO:1901607

Alpha-amino acid biosynthetic process

10 of 74

1.63

3.52

4.93e-13

GO:0009088

Threonine biosynthetic process

4 of 5

2.4

3.23

5.48e-07

GO:0009086

Methionine biosynthetic process

3 of 5

2.27

2.16

7.02e-05

GO:0009097

Isoleucine biosynthetic process

3 of 6

2.2

2.06

0.00010

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004795

Threonine synthase activity

2 of 2

2.5

0.81

0.0338

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

5 of 216

0.86

0.57

0.0134

GO:0005737

Cytoplasm

10 of 996

0.5

0.38

0.0040

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1023

Monobactam biosynthesis

4 of 5

2.4

2.75

5.38e-06

CL:821

Cellular amino acid metabolic process, and Nucleoside monophosphate metabolic process

7 of 144

1.18

1.28

2.91e-05

CL:822

Cellular amino acid metabolic process, and Nucleoside monophosphate metabolic process

6 of 131

1.16

1.13

0.00018

CL:823

Cellular amino acid metabolic process, and Nucleoside monophosphate metabolic process

5 of 121

1.11

0.89

0.0022

CL:2866

Threonine metabolic process, and Biotin metabolic process

2 of 7

1.95

0.82

0.0282

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

psac00270

Cysteine and methionine metabolism

6 of 19

2.0

3.86

1.09e-09

psac00261

Monobactam biosynthesis

4 of 5

2.4

3.52

1.34e-07

psac01230

Biosynthesis of amino acids

11 of 99

1.54

3.44

1.97e-15

psac00260

Glycine, serine and threonine metabolism

5 of 28

1.75

2.59

4.12e-07

psac00300

Lysine biosynthesis

4 of 16

1.89

2.47

3.62e-06

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0486

Methionine biosynthesis

3 of 4

2.37

2.17

7.93e-05

KW-0028

Amino-acid biosynthesis

5 of 48

1.51

1.66

5.72e-05

KW-0220

Diaminopimelate biosynthesis

2 of 4

2.2

1.1

0.0087

KW-0457

Lysine biosynthesis

2 of 6

2.02

1.01

0.0122

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045865

ACT-like domain

3 of 8

2.07

1.21

0.0050

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