node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SEH59017.1 | SEH59054.1 | SAMN05660691_00364 | SAMN05660691_00366 | Transcriptional regulator, BadM/Rrf2 family; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Nitrogen fixation protein NifU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.991 |
SEH59017.1 | SEH59070.1 | SAMN05660691_00364 | SAMN05660691_00367 | Transcriptional regulator, BadM/Rrf2 family; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Iron-sulfur cluster assembly protein; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | 0.960 |
SEH59017.1 | SEH59115.1 | SAMN05660691_00364 | SAMN05660691_00370 | Transcriptional regulator, BadM/Rrf2 family; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Ferredoxin, 2Fe-2S. | 0.830 |
SEH59017.1 | SEH71077.1 | SAMN05660691_00364 | SAMN05660691_00927 | Transcriptional regulator, BadM/Rrf2 family; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Cysteine sulfinate desulfinase/cysteine desulfurase. | 0.973 |
SEH59017.1 | SEI08698.1 | SAMN05660691_00364 | SAMN05660691_03484 | Transcriptional regulator, BadM/Rrf2 family; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | DnaJ like chaperone protein. | 0.534 |
SEH59017.1 | hscA | SAMN05660691_00364 | SAMN05660691_00369 | Transcriptional regulator, BadM/Rrf2 family; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Molecular chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. | 0.664 |
SEH59017.1 | hscB | SAMN05660691_00364 | SAMN05660691_00368 | Transcriptional regulator, BadM/Rrf2 family; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Molecular chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.968 |
SEH59017.1 | iscS | SAMN05660691_00364 | SAMN05660691_00365 | Transcriptional regulator, BadM/Rrf2 family; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.999 |
SEH59017.1 | nfuA | SAMN05660691_00364 | SAMN05660691_03086 | Transcriptional regulator, BadM/Rrf2 family; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Fe/S biogenesis protein NfuA; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.815 |
SEH59054.1 | SEH59017.1 | SAMN05660691_00366 | SAMN05660691_00364 | Nitrogen fixation protein NifU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Transcriptional regulator, BadM/Rrf2 family; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.991 |
SEH59054.1 | SEH59070.1 | SAMN05660691_00366 | SAMN05660691_00367 | Nitrogen fixation protein NifU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Iron-sulfur cluster assembly protein; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | 0.991 |
SEH59054.1 | SEH59115.1 | SAMN05660691_00366 | SAMN05660691_00370 | Nitrogen fixation protein NifU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Ferredoxin, 2Fe-2S. | 0.998 |
SEH59054.1 | SEH71077.1 | SAMN05660691_00366 | SAMN05660691_00927 | Nitrogen fixation protein NifU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Cysteine sulfinate desulfinase/cysteine desulfurase. | 0.999 |
SEH59054.1 | SEI08698.1 | SAMN05660691_00366 | SAMN05660691_03484 | Nitrogen fixation protein NifU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | DnaJ like chaperone protein. | 0.991 |
SEH59054.1 | dnaK | SAMN05660691_00366 | SAMN05660691_02844 | Nitrogen fixation protein NifU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.969 |
SEH59054.1 | hscA | SAMN05660691_00366 | SAMN05660691_00369 | Nitrogen fixation protein NifU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Molecular chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. | 0.996 |
SEH59054.1 | hscB | SAMN05660691_00366 | SAMN05660691_00368 | Nitrogen fixation protein NifU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Molecular chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.999 |
SEH59054.1 | iscS | SAMN05660691_00366 | SAMN05660691_00365 | Nitrogen fixation protein NifU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.999 |
SEH59054.1 | nfuA | SAMN05660691_00366 | SAMN05660691_03086 | Nitrogen fixation protein NifU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Fe/S biogenesis protein NfuA; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.977 |
SEH59070.1 | SEH59017.1 | SAMN05660691_00367 | SAMN05660691_00364 | Iron-sulfur cluster assembly protein; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | Transcriptional regulator, BadM/Rrf2 family; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.960 |