A0A2J6QME5 protein (Pezoloma ericae) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

A0A2J6QME5

RNA-binding domain-containing protein. (162 aa)

Predicted Functional Partners:

A0A2J6PZQ8

0.974

A0A2J6QCN8

0.974

A0A2J6QFZ0

0.965

A0A2J6QI83

0.944

A0A2J6Q679

0.938

A0A2J6Q3K8

0.919

A0A2J6PFP6

0.917

A0A2J6QCV2

0.912

A0A2J6QA64

0.903

A0A2J6QMF5

0.901

Your Current Organism:

Pezoloma ericae

NCBI taxonomy Id: 1745343
Other names: Hymenoscyphus ericae, P. ericae, Pezizella ericae, Pezizella ericae D.J.Read, Pezoloma ericae (D.J. Read) Baral, 2006, Rhizoscyphus ericae, UAMH 6735

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A2J6PFP6	A0A2J6PZQ8	RRM domain-containing protein.	Nuclear cap-binding protein subunit 2.	0.868
A0A2J6PFP6	A0A2J6Q3K8	RRM domain-containing protein.	RNA-binding domain-containing protein.	0.732
A0A2J6PFP6	A0A2J6QCN8	RRM domain-containing protein.	Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's.	0.983
A0A2J6PFP6	A0A2J6QFZ0	RRM domain-containing protein.	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family.	0.725
A0A2J6PFP6	A0A2J6QME5	RRM domain-containing protein.	RNA-binding domain-containing protein.	0.917
A0A2J6PZQ8	A0A2J6PFP6	Nuclear cap-binding protein subunit 2.	RRM domain-containing protein.	0.868
A0A2J6PZQ8	A0A2J6Q3K8	Nuclear cap-binding protein subunit 2.	RNA-binding domain-containing protein.	0.985
A0A2J6PZQ8	A0A2J6Q679	Nuclear cap-binding protein subunit 2.	Eukaryotic initiation factor 4A-12; Belongs to the DEAD box helicase family.	0.892
A0A2J6PZQ8	A0A2J6QA64	Nuclear cap-binding protein subunit 2.	MIF4G domain-containing protein.	0.738
A0A2J6PZQ8	A0A2J6QCN8	Nuclear cap-binding protein subunit 2.	Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's.	0.934
A0A2J6PZQ8	A0A2J6QFZ0	Nuclear cap-binding protein subunit 2.	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family.	0.948
A0A2J6PZQ8	A0A2J6QME5	Nuclear cap-binding protein subunit 2.	RNA-binding domain-containing protein.	0.974
A0A2J6Q3K8	A0A2J6PFP6	RNA-binding domain-containing protein.	RRM domain-containing protein.	0.732
A0A2J6Q3K8	A0A2J6PZQ8	RNA-binding domain-containing protein.	Nuclear cap-binding protein subunit 2.	0.985
A0A2J6Q3K8	A0A2J6Q679	RNA-binding domain-containing protein.	Eukaryotic initiation factor 4A-12; Belongs to the DEAD box helicase family.	0.997
A0A2J6Q3K8	A0A2J6QA64	RNA-binding domain-containing protein.	MIF4G domain-containing protein.	0.989
A0A2J6Q3K8	A0A2J6QCV2	RNA-binding domain-containing protein.	Uncharacterized protein.	0.904
A0A2J6Q3K8	A0A2J6QFZ0	RNA-binding domain-containing protein.	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family.	0.673
A0A2J6Q3K8	A0A2J6QI83	RNA-binding domain-containing protein.	SAP domain-containing protein.	0.825
A0A2J6Q3K8	A0A2J6QME5	RNA-binding domain-containing protein.	RNA-binding domain-containing protein.	0.919

page 1 of 4

Network Stats

number of nodes:

3

number of edges:

3

average node degree:

2

avg. local clustering coefficient:

1

expected number of edges:

2

PPI enrichment p-value:

0.216

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007021

Tubulin complex assembly

4 of 9

2.43

2.66

8.92e-06

GO:0015976

Carbon utilization

3 of 6

2.49

1.81

0.00044

GO:0071244

Cellular response to carbon dioxide

2 of 2

2.79

1.06

0.0119

GO:0007023

Post-chaperonin tubulin folding pathway

2 of 3

2.61

1.03

0.0132

GO:0006457

Protein folding

4 of 88

1.44

0.89

0.0109

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004089

Carbonate dehydratase activity

3 of 5

2.56

1.95

0.00025

GO:0015631

Tubulin binding

4 of 37

1.82

1.7

0.00026

GO:0048487

Beta-tubulin binding

2 of 2

2.79

1.2

0.0066

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005874

Microtubule

4 of 35

1.84

1.75

0.00021

GO:0015630

Microtubule cytoskeleton

5 of 94

1.51

1.5

0.00021

GO:0099080

Supramolecular complex

5 of 117

1.42

1.41

0.00021

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9794

Tubulin complex assembly, and Alpha-tubulin binding

6 of 10

2.56

5.36

3.12e-11

CL:9799

Beta-tubulin binding, and CAP Gly-rich domain

5 of 5

2.79

4.97

4.45e-10

CL:5291

Mixed, incl. Carbonate dehydratase activity, and Atypical dual-specificity phosphatase Siw14-like

3 of 26

1.85

1.25

0.0032

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00910

Nitrogen metabolism

3 of 12

2.18

1.91

0.00020

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-391251

Protein folding

4 of 24

2.01

2.05

6.85e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036874

Carbonic anhydrase superfamily

2 of 2

2.79

0.82

0.0332

IPR001765

Carbonic anhydrase

2 of 2

2.79

0.82

0.0332

IPR036859

CAP Gly-rich domain superfamily

2 of 4

2.49

0.81

0.0332

IPR000938

CAP Gly-rich domain

2 of 4

2.49

0.81

0.0332

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00947

Carbonic anhydrase

2 of 2

2.79

1.34

0.0037

SM01052

Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including ...

2 of 4

2.49

1.27

0.0046

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