STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiEThiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (216 aa)    
Predicted Functional Partners:
ALT36333.1
4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Catalyzes the formation of 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate with the subsequent phosphorylation to form 4-amino-5-hydroxymethyl-2-methyl-pyrimidine pyrophosphate and catalyzes the hydrolysis of 4-amino-5-aminomethyl-2-methylpyrimidine to form hydroxy-pyrimidine; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.999
ALT35109.1
Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ). Belongs to the Thz kinase family.
 
 0.999
ALT35796.1
Phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.993
ALT35505.1
Thiamine monophosphate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.984
ALT34466.1
Thiamine-phosphate pyrophosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 
0.924
ALT35432.1
GTPase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.909
ALT34815.1
Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.881
ALT36389.1
Thiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.752
ALT34510.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
      0.745
ALT34465.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.683
Your Current Organism:
Cutibacterium acnes
NCBI taxonomy Id: 1747
Other names: ATCC 6919, Bacillus acnes, C. acnes, CIP 53.117, Corynebacterium acnes, DSM 16379, JCM 6425, LMG 16711, LMG:16711, NCTC 737, NRRL B-4224, Propionibacterium acnes, Propionicibacterium acnes
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.