STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ALT35819.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (327 aa)    
Predicted Functional Partners:
fumC
Fumarate hydratase; Class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.982
gltA
Type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family.
  
 0.976
ALT36248.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.976
ALT34642.1
Malate oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.949
ALT35111.1
Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the malic enzymes family.
  
 0.949
ALT36299.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.900
ALT34508.1
Pyruvate-flavodoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.890
ALT35317.1
Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.887
purU
Formyltetrahydrofolate deformylase; Produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.886
ALT35817.1
Isocitrate dehydrogenase; NADP-specific, catalyzes the formation of 2-oxoglutarate from isocitrate or oxalosuccinate; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.869
Your Current Organism:
Cutibacterium acnes
NCBI taxonomy Id: 1747
Other names: ATCC 6919, Bacillus acnes, C. acnes, CIP 53.117, Corynebacterium acnes, DSM 16379, JCM 6425, LMG 16711, LMG:16711, NCTC 737, NRRL B-4224, Propionibacterium acnes, Propionicibacterium acnes
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