A0A1Y1WP57 protein (Anaeromyces robustus) - STRING interaction network

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

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[Homology]

Score

A0A1Y1WP57

TPR-like protein. (508 aa)

Predicted Functional Partners:

A0A1Y1XNI5

0.978

A0A1Y1WRQ2

0.974

A0A1Y1XM69

0.974

A0A1Y1VY99

0.973

A0A1Y1WJ48

0.972

A0A1Y1XAE6

0.972

A0A1Y1XIV1

0.971

A0A1Y1X5Q9

0.968

ALA1

0.938

A0A1Y1V1W1

0.935

Your Current Organism:

Anaeromyces robustus

NCBI taxonomy Id: 1754192
Other names: A. robustus, Anaeromyces sp. KS-2015, Anaeromyces sp. S4, JMRC:SF:12178, S4

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1Y1V1W1	A0A1Y1VY99	A0A1Y1V1W1	A0A1Y1VY99	WD40 repeat-like protein.	ANAPC5 domain-containing protein.	0.957
A0A1Y1V1W1	A0A1Y1WJ48	A0A1Y1V1W1	A0A1Y1WJ48	WD40 repeat-like protein.	TPR-like protein.	0.973
A0A1Y1V1W1	A0A1Y1WP57	A0A1Y1V1W1	A0A1Y1WP57	WD40 repeat-like protein.	TPR-like protein.	0.935
A0A1Y1V1W1	A0A1Y1WRQ2	A0A1Y1V1W1	A0A1Y1WRQ2	WD40 repeat-like protein.	APC1_C domain-containing protein.	0.966
A0A1Y1V1W1	A0A1Y1X5Q9	A0A1Y1V1W1	A0A1Y1X5Q9	WD40 repeat-like protein.	TPR-like protein.	0.935
A0A1Y1V1W1	A0A1Y1XAE6	A0A1Y1V1W1	A0A1Y1XAE6	WD40 repeat-like protein.	RING/U-box.	0.945
A0A1Y1V1W1	A0A1Y1XIV1	A0A1Y1V1W1	A0A1Y1XIV1	WD40 repeat-like protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.955
A0A1Y1V1W1	A0A1Y1XM69	A0A1Y1V1W1	A0A1Y1XM69	WD40 repeat-like protein.	Uncharacterized protein.	0.968
A0A1Y1V1W1	A0A1Y1XNI5	A0A1Y1V1W1	A0A1Y1XNI5	WD40 repeat-like protein.	TPR-like protein.	0.968
A0A1Y1V1W1	ALA1	A0A1Y1V1W1	A0A1Y1XPP5	WD40 repeat-like protein.	Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family.	0.679
A0A1Y1VY99	A0A1Y1V1W1	A0A1Y1VY99	A0A1Y1V1W1	ANAPC5 domain-containing protein.	WD40 repeat-like protein.	0.957
A0A1Y1VY99	A0A1Y1WJ48	A0A1Y1VY99	A0A1Y1WJ48	ANAPC5 domain-containing protein.	TPR-like protein.	0.999
A0A1Y1VY99	A0A1Y1WP57	A0A1Y1VY99	A0A1Y1WP57	ANAPC5 domain-containing protein.	TPR-like protein.	0.973
A0A1Y1VY99	A0A1Y1WRQ2	A0A1Y1VY99	A0A1Y1WRQ2	ANAPC5 domain-containing protein.	APC1_C domain-containing protein.	0.999
A0A1Y1VY99	A0A1Y1X5Q9	A0A1Y1VY99	A0A1Y1X5Q9	ANAPC5 domain-containing protein.	TPR-like protein.	0.998
A0A1Y1VY99	A0A1Y1XAE6	A0A1Y1VY99	A0A1Y1XAE6	ANAPC5 domain-containing protein.	RING/U-box.	0.999
A0A1Y1VY99	A0A1Y1XIV1	A0A1Y1VY99	A0A1Y1XIV1	ANAPC5 domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.999
A0A1Y1VY99	A0A1Y1XM69	A0A1Y1VY99	A0A1Y1XM69	ANAPC5 domain-containing protein.	Uncharacterized protein.	0.999
A0A1Y1VY99	A0A1Y1XNI5	A0A1Y1VY99	A0A1Y1XNI5	ANAPC5 domain-containing protein.	TPR-like protein.	0.999
A0A1Y1VY99	ALA1	A0A1Y1VY99	A0A1Y1XPP5	ANAPC5 domain-containing protein.	Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family.	0.971

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Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.782

expected number of edges:

22

PPI enrichment p-value:

0.778

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018106

Peptidyl-histidine phosphorylation

6 of 58

1.72

2.5

5.81e-07

GO:0000160

Phosphorelay signal transduction system

6 of 94

1.51

1.98

3.00e-06

GO:0016310

Phosphorylation

7 of 189

1.27

1.56

3.64e-06

GO:0050896

Response to stimulus

10 of 452

1.05

1.26

2.06e-07

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004673

Protein histidine kinase activity

7 of 62

1.76

3.08

8.78e-09

GO:0000155

Phosphorelay sensor kinase activity

3 of 35

1.64

1.09

0.0050

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3899

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain, and Signal transduction response regulator, receiver domain

7 of 19

2.27

5.41

2.04e-12

CL:3897

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily, and OmpR/PhoB-type DNA-binding domain

8 of 30

2.13

5.31

4.33e-13

CL:3901

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain, and PAS fold-3

4 of 11

2.27

2.91

1.75e-06

CL:3903

PAS fold, and PAS fold-4

3 of 5

2.48

2.32

4.49e-05

CL:3923

Mixed, incl. Peptidyl-aspartic acid modification, and Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

3 of 7

2.34

2.14

8.64e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lagg02020

Two-component system

6 of 141

1.33

1.55

1.50e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

8 of 72

1.75

3.6

4.49e-11

KW-0418

Kinase

5 of 115

1.34

1.33

0.00020

KW-0808

Transferase

6 of 620

0.69

0.4

0.0413

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

7 of 34

2.02

4.19

1.48e-10

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

7 of 36

1.99

4.13

1.48e-10

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

7 of 38

1.97

4.07

1.58e-10

IPR005467

Histidine kinase domain

7 of 39

1.96

4.04

1.58e-10

IPR003594

Histidine kinase/HSP90-like ATPase

7 of 42

1.93

3.93

2.13e-10

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

7 of 39

1.96

4.23

3.66e-11

SM00387

Histidine kinase-like ATPases

7 of 44

1.91

4.05

5.27e-11

SM00448

cheY-homologous receiver domain

8 of 67

1.78

3.8

1.64e-11

SM00091

PAS domain

4 of 33

1.79

2.11

1.86e-05

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

2 of 23

1.64

0.77

0.0295

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