A0A1Y1WV67 protein (Anaeromyces robustus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A1Y1WV67

Uncharacterized protein. (1282 aa)

Predicted Functional Partners:

A0A1Y1XL74

0.945

A0A1Y1XDW5

0.939

A0A1Y1WY73

0.910

A0A1Y1WZ47

0.890

A0A1Y1XQH1

0.833

A0A1Y1VPV7

0.825

A0A1Y1VYA0

0.825

A0A1Y1WGS6

0.825

A0A1Y1WQ37

0.825

A0A1Y1XGT0

0.825

Your Current Organism:

Anaeromyces robustus

NCBI taxonomy Id: 1754192
Other names: A. robustus, Anaeromyces sp. KS-2015, Anaeromyces sp. S4, JMRC:SF:12178, S4

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1Y1VPV7	A0A1Y1WV67	Uncharacterized protein.	Uncharacterized protein.	0.825
A0A1Y1VPV7	A0A1Y1WY73	Uncharacterized protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.915
A0A1Y1VPV7	A0A1Y1WZ47	Uncharacterized protein.	ERCC4 domain-containing protein.	0.903
A0A1Y1VPV7	A0A1Y1XDW5	Uncharacterized protein.	ERCC4 domain-containing protein.	0.898
A0A1Y1VPV7	A0A1Y1XL74	Uncharacterized protein.	RMI1_N domain-containing protein.	0.905
A0A1Y1VPV7	A0A1Y1XQH1	Uncharacterized protein.	Zinc-hook domain-containing protein.	0.831
A0A1Y1VYA0	A0A1Y1WV67	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	Uncharacterized protein.	0.825
A0A1Y1VYA0	A0A1Y1WY73	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.915
A0A1Y1VYA0	A0A1Y1WZ47	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	ERCC4 domain-containing protein.	0.903
A0A1Y1VYA0	A0A1Y1XDW5	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	ERCC4 domain-containing protein.	0.898
A0A1Y1VYA0	A0A1Y1XL74	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	RMI1_N domain-containing protein.	0.905
A0A1Y1VYA0	A0A1Y1XQH1	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	Zinc-hook domain-containing protein.	0.831
A0A1Y1WGS6	A0A1Y1WV67	ATP-dependent DNA helicase.	Uncharacterized protein.	0.825
A0A1Y1WGS6	A0A1Y1WY73	ATP-dependent DNA helicase.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.915
A0A1Y1WGS6	A0A1Y1WZ47	ATP-dependent DNA helicase.	ERCC4 domain-containing protein.	0.903
A0A1Y1WGS6	A0A1Y1XDW5	ATP-dependent DNA helicase.	ERCC4 domain-containing protein.	0.898
A0A1Y1WGS6	A0A1Y1XL74	ATP-dependent DNA helicase.	RMI1_N domain-containing protein.	0.905
A0A1Y1WGS6	A0A1Y1XQH1	ATP-dependent DNA helicase.	Zinc-hook domain-containing protein.	0.831
A0A1Y1WQ37	A0A1Y1WV67	ATP-dependent DNA helicase.	Uncharacterized protein.	0.825
A0A1Y1WQ37	A0A1Y1WY73	ATP-dependent DNA helicase.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.912

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.731

expected number of edges:

12

PPI enrichment p-value:

1.63e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006534

Cysteine metabolic process

10 of 25

2.55

9.78

1.32e-21

GO:0019346

Transsulfuration

5 of 9

2.7

5.11

1.82e-10

GO:0006535

Cysteine biosynthetic process from serine

5 of 12

2.57

4.84

4.01e-10

GO:1901605

Alpha-amino acid metabolic process

11 of 169

1.76

4.79

2.16e-17

GO:1901566

Organonitrogen compound biosynthetic process

6 of 576

0.97

0.83

0.00076

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009001

Serine O-acetyltransferase activity

4 of 7

2.71

3.54

2.48e-07

GO:0102028

Cystathionine gamma-synthase activity (acts on O-phosphohomoserine)

3 of 3

2.95

3.06

2.57e-06

GO:0003962

Cystathionine gamma-synthase activity

3 of 3

2.95

3.06

2.57e-06

GO:0030170

Pyridoxal phosphate binding

5 of 49

1.96

2.9

4.15e-07

GO:0016765

Transferase activity, transferring alkyl or aryl (other than methyl) groups

4 of 46

1.89

2.22

1.70e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 2163

0.66

0.61

9.66e-06

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7368

Cysteine biosynthetic process from serine, and Cystathionine gamma-synthase activity

7 of 13

2.68

7.15

9.12e-15

CL:7367

Sulfur amino acid metabolic process, and Methionine adenosyltransferase activity

8 of 25

2.46

7.02

1.99e-15

CL:7370

Cysteine biosynthetic process from serine

3 of 7

2.58

2.4

3.36e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00270

Cysteine and methionine metabolism

10 of 90

2.0

6.06

1.11e-17

map00450

Selenocompound metabolism

5 of 23

2.29

4.18

2.66e-09

map01230

Biosynthesis of amino acids

8 of 187

1.58

2.95

2.22e-10

map00920

Sulfur metabolism

4 of 65

1.74

2.08

1.60e-05

map01200

Carbon metabolism

4 of 160

1.35

1.25

0.00044

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0663

Pyridoxal phosphate

4 of 48

1.87

2.02

4.97e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00132

Bacterial transferase hexapeptide (six repeats)

3 of 13

2.31

1.75

0.00051

PF01053

Cys/Met metabolism PLP-dependent enzyme

2 of 4

2.65

1.17

0.0075

PF00155

Aminotransferase class I and II

2 of 14

2.11

0.75

0.0399

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000277

Cys/Met metabolism, pyridoxal phosphate-dependent enzyme

5 of 6

2.87

4.95

5.99e-10

IPR045304

Serine acetyltransferase, LbH domain

4 of 4

2.95

3.91

6.38e-08

IPR011004

Trimeric LpxA-like superfamily

4 of 17

2.32

2.86

2.71e-06

IPR005881

Serine O-acetyltransferase

3 of 3

2.95

2.77

8.96e-06

IPR015424

Pyridoxal phosphate-dependent transferase

5 of 49

1.96

2.71

1.34e-06

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (18%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About