A0A1Y1XJG3 protein (Anaeromyces robustus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

A0A1Y1XJG3

SWIRM-domain-containing protein. (550 aa)

Predicted Functional Partners:

A0A1Y1XNU5

0.976

A0A1Y1X6K0

0.971

A0A1Y1X7W6

0.971

A0A1Y1WQE1

0.963

A0A1Y1X5J9

0.955

A0A1Y1X7M0

0.955

A0A1Y1X0L5

0.938

A0A1Y1WWS7

0.935

A0A1Y1XQP6

0.873

A0A1Y1WVK0

0.832

Your Current Organism:

Anaeromyces robustus

NCBI taxonomy Id: 1754192
Other names: A. robustus, Anaeromyces sp. KS-2015, Anaeromyces sp. S4, JMRC:SF:12178, S4

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1Y1WQE1	A0A1Y1WWS7	Bromodomain-containing protein.	SNF5-domain-containing protein.	0.946
A0A1Y1WQE1	A0A1Y1X0L5	Bromodomain-containing protein.	SNF5-domain-containing protein.	0.946
A0A1Y1WQE1	A0A1Y1X5J9	Bromodomain-containing protein.	ARID domain-containing protein.	0.981
A0A1Y1WQE1	A0A1Y1X6K0	Bromodomain-containing protein.	Uncharacterized protein.	0.982
A0A1Y1WQE1	A0A1Y1X7M0	Bromodomain-containing protein.	Actin/actin-like protein; Belongs to the actin family.	0.964
A0A1Y1WQE1	A0A1Y1X7W6	Bromodomain-containing protein.	SWI/SNF and RSC complex subunit Ssr3.	0.983
A0A1Y1WQE1	A0A1Y1XJG3	Bromodomain-containing protein.	SWIRM-domain-containing protein.	0.963
A0A1Y1WQE1	A0A1Y1XNU5	Bromodomain-containing protein.	Bromodomain-domain-containing protein.	0.983
A0A1Y1WQE1	A0A1Y1XQP6	Bromodomain-containing protein.	SWIB-domain-containing protein.	0.947
A0A1Y1WVK0	A0A1Y1WWS7	BAF250_C domain-containing protein.	SNF5-domain-containing protein.	0.867
A0A1Y1WVK0	A0A1Y1X0L5	BAF250_C domain-containing protein.	SNF5-domain-containing protein.	0.943
A0A1Y1WVK0	A0A1Y1X6K0	BAF250_C domain-containing protein.	Uncharacterized protein.	0.941
A0A1Y1WVK0	A0A1Y1X7M0	BAF250_C domain-containing protein.	Actin/actin-like protein; Belongs to the actin family.	0.737
A0A1Y1WVK0	A0A1Y1X7W6	BAF250_C domain-containing protein.	SWI/SNF and RSC complex subunit Ssr3.	0.891
A0A1Y1WVK0	A0A1Y1XJG3	BAF250_C domain-containing protein.	SWIRM-domain-containing protein.	0.832
A0A1Y1WVK0	A0A1Y1XNU5	BAF250_C domain-containing protein.	Bromodomain-domain-containing protein.	0.769
A0A1Y1WVK0	A0A1Y1XQP6	BAF250_C domain-containing protein.	SWIB-domain-containing protein.	0.524
A0A1Y1WWS7	A0A1Y1WQE1	SNF5-domain-containing protein.	Bromodomain-containing protein.	0.946
A0A1Y1WWS7	A0A1Y1WVK0	SNF5-domain-containing protein.	BAF250_C domain-containing protein.	0.867
A0A1Y1WWS7	A0A1Y1X5J9	SNF5-domain-containing protein.	ARID domain-containing protein.	0.963

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.879

expected number of edges:

11

PPI enrichment p-value:

0.000151

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1905515

Non-motile cilium assembly

3 of 28

2.32

1.81

0.00039

GO:0060271

Cilium assembly

5 of 196

1.7

1.69

0.00016

GO:0035973

Aggrephagy

2 of 5

2.89

1.49

0.0020

GO:0000423

Mitophagy

2 of 7

2.74

1.39

0.0030

GO:0016050

Vesicle organization

3 of 100

1.77

1.13

0.0053

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070530

K63-linked polyubiquitin modification-dependent protein binding

2 of 12

2.51

0.78

0.0389

GO:0005080

Protein kinase C binding

2 of 12

2.51

0.78

0.0389

GO:0005515

Protein binding

8 of 3064

0.71

0.41

0.0389

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034464

BBSome

4 of 6

3.11

4.43

7.94e-09

GO:0060170

Ciliary membrane

3 of 18

2.51

2.39

3.35e-05

GO:0005813

Centrosome

5 of 205

1.68

2.04

1.28e-05

GO:0005815

Microtubule organizing center

6 of 333

1.54

2.02

3.28e-06

GO:0044753

Amphisome

2 of 3

3.11

1.92

0.00034

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15359

BBSome

5 of 6

3.21

6.09

7.07e-12

CL:15347

Mixed, incl. BBSome, and Genitalia morphogenesis

6 of 23

2.7

5.88

5.00e-12

CL:14124

Mixed, incl. Amphisome, and AhpD-like

2 of 6

2.81

1.54

0.0016

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5620920

Cargo trafficking to the periciliary membrane

5 of 56

2.24

3.46

9.39e-08

MAP-9755511

KEAP1-NFE2L2 pathway

5 of 60

2.21

3.43

9.39e-08

MAP-9711123

Cellular response to chemical stress

5 of 117

1.92

2.7

1.07e-06

MAP-5617833

Cilium Assembly

5 of 206

1.67

2.04

1.27e-05

MAP-1852241

Organelle biogenesis and maintenance

5 of 236

1.61

1.91

1.97e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0034464

BBSome

4 of 5

3.19

4.54

5.34e-09

GOCC:0005929

Cilium

5 of 269

1.56

1.67

8.09e-05

GOCC:0005776

Autophagosome

2 of 26

2.17

0.91

0.0202

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045093

Cullin

2 of 5

2.89

1.01

0.0149

IPR036317

Cullin homology domain superfamily

2 of 6

2.81

1.01

0.0149

IPR019559

Cullin protein, neddylation domain

2 of 4

2.99

1.01

0.0149

IPR016158

Cullin homology domain

2 of 5

2.89

1.01

0.0149

IPR001373

Cullin, N-terminal

2 of 6

2.81

1.01

0.0149

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00884

Cullin protein neddylation domain

2 of 4

2.99

1.48

0.0021

SM00182

Cullin

2 of 5

2.89

1.48

0.0021

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