A0A1Y1XPQ5 protein (Anaeromyces robustus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

A0A1Y1XPQ5

G10 protein. (145 aa)

Predicted Functional Partners:

A0A1Y1X0D9

0.999

A0A1Y1X7Q9

0.999

A0A1Y1XEL3

0.999

A0A1Y1XP02

0.999

A0A1Y1XP89

0.999

A0A1Y1XAC8

0.998

A0A1Y1XMY7

0.998

A0A1Y1X8P9

0.990

A0A1Y1XIE1

0.989

A0A1Y1XIX7

0.989

Your Current Organism:

Anaeromyces robustus

NCBI taxonomy Id: 1754192
Other names: A. robustus, Anaeromyces sp. KS-2015, Anaeromyces sp. S4, JMRC:SF:12178, S4

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1Y1X0D9	A0A1Y1X7Q9	Pre-mRNA-splicing factor ISY1.	SKIP_SNW domain-containing protein.	0.998
A0A1Y1X0D9	A0A1Y1X8P9	Pre-mRNA-splicing factor ISY1.	Cwf15/Cwc15 cell cycle control protein.	0.944
A0A1Y1X0D9	A0A1Y1XAC8	Pre-mRNA-splicing factor ISY1.	P-loop containing nucleoside triphosphate hydrolase protein.	0.998
A0A1Y1X0D9	A0A1Y1XEL3	Pre-mRNA-splicing factor ISY1.	TPR-like protein.	0.999
A0A1Y1X0D9	A0A1Y1XIE1	Pre-mRNA-splicing factor ISY1.	WD40 repeat-like protein.	0.983
A0A1Y1X0D9	A0A1Y1XIX7	Pre-mRNA-splicing factor ISY1.	MIF4G-domain-containing protein.	0.937
A0A1Y1X0D9	A0A1Y1XMY7	Pre-mRNA-splicing factor ISY1.	Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.	0.995
A0A1Y1X0D9	A0A1Y1XP02	Pre-mRNA-splicing factor ISY1.	Pre-mRNA-splicing factor RBM22.	0.998
A0A1Y1X0D9	A0A1Y1XP89	Pre-mRNA-splicing factor ISY1.	TPR-like protein.	0.999
A0A1Y1X0D9	A0A1Y1XPQ5	Pre-mRNA-splicing factor ISY1.	G10 protein.	0.999
A0A1Y1X7Q9	A0A1Y1X0D9	SKIP_SNW domain-containing protein.	Pre-mRNA-splicing factor ISY1.	0.998
A0A1Y1X7Q9	A0A1Y1X8P9	SKIP_SNW domain-containing protein.	Cwf15/Cwc15 cell cycle control protein.	0.989
A0A1Y1X7Q9	A0A1Y1XAC8	SKIP_SNW domain-containing protein.	P-loop containing nucleoside triphosphate hydrolase protein.	0.997
A0A1Y1X7Q9	A0A1Y1XEL3	SKIP_SNW domain-containing protein.	TPR-like protein.	0.999
A0A1Y1X7Q9	A0A1Y1XIE1	SKIP_SNW domain-containing protein.	WD40 repeat-like protein.	0.989
A0A1Y1X7Q9	A0A1Y1XIX7	SKIP_SNW domain-containing protein.	MIF4G-domain-containing protein.	0.968
A0A1Y1X7Q9	A0A1Y1XMY7	SKIP_SNW domain-containing protein.	Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.	0.997
A0A1Y1X7Q9	A0A1Y1XP02	SKIP_SNW domain-containing protein.	Pre-mRNA-splicing factor RBM22.	0.999
A0A1Y1X7Q9	A0A1Y1XP89	SKIP_SNW domain-containing protein.	TPR-like protein.	0.999
A0A1Y1X7Q9	A0A1Y1XPQ5	SKIP_SNW domain-containing protein.	G10 protein.	0.999

page 1 of 6

Network Stats

number of nodes:

8

number of edges:

21

average node degree:

5.25

avg. local clustering coefficient:

0.925

expected number of edges:

7

PPI enrichment p-value:

1.98e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009082

Branched-chain amino acid biosynthetic process

8 of 14

2.22

5.61

2.59e-13

GO:0009098

Leucine biosynthetic process

5 of 8

2.25

3.67

3.28e-08

GO:0009097

Isoleucine biosynthetic process

4 of 7

2.22

2.84

2.13e-06

GO:1901607

Alpha-amino acid biosynthetic process

8 of 72

1.5

2.47

7.45e-09

GO:0009099

Valine biosynthetic process

3 of 4

2.33

2.19

6.74e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003861

3-isopropylmalate dehydratase activity

2 of 2

2.46

0.77

0.0403

GO:0016836

Hydro-lyase activity

3 of 29

1.47

0.67

0.0403

GO:0000287

Magnesium ion binding

4 of 64

1.25

0.62

0.0403

GO:0019842

Vitamin binding

3 of 39

1.34

0.62

0.0468

GO:0016829

Lyase activity

4 of 103

1.05

0.53

0.0468

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009316

3-isopropylmalate dehydratase complex

2 of 2

2.46

1.43

0.0023

GO:0005829

Cytosol

8 of 308

0.87

0.79

0.00016

GO:0005737

Cytoplasm

11 of 1058

0.48

0.4

0.00043

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1004

2-Oxocarboxylic acid metabolism, and Aspartate family amino acid biosynthetic process

9 of 43

1.78

4.01

1.51e-12

CL:1067

C5-Branched dibasic acid metabolism

5 of 8

2.25

3.69

2.97e-08

CL:1002

Cellular amino acid biosynthetic process, and Aminotransferase, class I/classII

10 of 86

1.52

3.05

1.51e-12

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

blep00290

Valine, leucine and isoleucine biosynthesis

10 of 13

2.34

8.38

4.80e-20

blep01210

2-Oxocarboxylic acid metabolism

8 of 26

1.95

4.69

6.24e-13

blep00770

Pantothenate and CoA biosynthesis

5 of 13

2.04

3.43

3.12e-08

blep00660

C5-Branched dibasic acid metabolism

4 of 10

2.06

2.83

1.18e-06

blep01230

Biosynthesis of amino acids

9 of 99

1.42

2.5

6.15e-11

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009316

3-isopropylmalate dehydratase complex

2 of 2

2.46

1.25

0.0050

GOCC:0005829

Cytosol

9 of 530

0.69

0.57

0.00067

GOCC:0005737

Cytoplasm

11 of 883

0.55

0.47

0.00026

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0100

Branched-chain amino acid biosynthesis

9 of 11

2.37

7.54

2.25e-17

KW-0432

Leucine biosynthesis

4 of 4

2.46

3.33

3.93e-07

KW-0456

Lyase

4 of 69

1.22

0.91

0.0041

KW-0460

Magnesium

4 of 102

1.05

0.69

0.0117

KW-0479

Metal-binding

6 of 276

0.8

0.57

0.0064

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