ANP44776.1 protein (Caulobacteraceae bacterium OTSzA272)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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[Homology]

Score

ANP44776.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0312 family. (223 aa)

Predicted Functional Partners:

ANP44703.1

0.527

ANP44777.1

0.522

ANP44778.1

0.511

ANP45000.1

0.422

Your Current Organism:

Caulobacteraceae bacterium OTSzA272

NCBI taxonomy Id: 1759059
Other names: C. bacterium OTSz_A_272, Caulobacteraceae bacterium OTSz_A_272

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANP44703.1	ANP44776.1	ATE48_01585	ATE48_01965	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0312 family.	0.527
ANP44703.1	ANP45000.1	ATE48_01585	ATE48_03230	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0312 family.	0.766
ANP44776.1	ANP44703.1	ATE48_01965	ATE48_01585	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0312 family.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.527
ANP44776.1	ANP44777.1	ATE48_01965	ATE48_01970	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0312 family.	thiJ/pfpI-family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.522
ANP44776.1	ANP44778.1	ATE48_01965	ATE48_01975	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0312 family.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.511
ANP44776.1	ANP45000.1	ATE48_01965	ATE48_03230	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0312 family.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0312 family.	0.422
ANP44777.1	ANP44776.1	ATE48_01970	ATE48_01965	thiJ/pfpI-family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0312 family.	0.522
ANP44777.1	ANP44778.1	ATE48_01970	ATE48_01975	thiJ/pfpI-family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.773
ANP44778.1	ANP44776.1	ATE48_01975	ATE48_01965	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0312 family.	0.511
ANP44778.1	ANP44777.1	ATE48_01975	ATE48_01970	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	thiJ/pfpI-family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.773
ANP45000.1	ANP44703.1	ATE48_03230	ATE48_01585	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0312 family.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.766
ANP45000.1	ANP44776.1	ATE48_03230	ATE48_01965	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0312 family.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0312 family.	0.422

Network Stats

number of nodes:

6

number of edges:

6

average node degree:

2

avg. local clustering coefficient:

0.85

expected number of edges:

5

PPI enrichment p-value:

0.386

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006631

Fatty acid metabolic process

8 of 150

1.72

3.19

1.09e-09

GO:0006633

Fatty acid biosynthetic process

6 of 75

1.89

2.98

1.27e-07

GO:0045471

Response to ethanol

3 of 5

2.77

2.58

1.82e-05

GO:0006636

Unsaturated fatty acid biosynthetic process

3 of 7

2.62

2.42

3.19e-05

GO:0000001

Mitochondrion inheritance

3 of 13

2.35

2.12

9.57e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004768

stearoyl-CoA 9-desaturase activity

3 of 4

2.86

2.38

4.47e-05

GO:0004312

Fatty acid synthase activity

3 of 37

1.9

1.27

0.0031

GO:0016491

Oxidoreductase activity

7 of 1415

0.68

0.39

0.0460

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030176

Integral component of endoplasmic reticulum membrane

3 of 55

1.72

0.86

0.0202

GO:0005737

Cytoplasm

11 of 4644

0.36

0.27

0.0289

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10250

Mixed, incl. Thioesterase, and Pigmentation

3 of 7

2.62

2.02

0.00019

CL:11013

Fatty acid metabolism, and Very long-chain fatty acid biosynthetic process

3 of 12

2.39

1.84

0.00036

CL:11230

Acyltransferase ChoActase/COT/CPT, and acyl-CoA oxidase activity

2 of 5

2.59

1.34

0.0035

CL:11025

Fatty acid desaturase type 1, conserved site, and Fatty acid elongase activity

2 of 6

2.51

1.31

0.0040

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01212

Fatty acid metabolism

6 of 152

1.58

2.27

6.14e-07

map00061

Fatty acid biosynthesis

3 of 43

1.83

1.48

0.00090

map01040

Biosynthesis of unsaturated fatty acids

3 of 94

1.49

1.05

0.0044

map01100

Metabolic pathways

10 of 3422

0.45

0.35

0.0044

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8978868

Fatty acid metabolism

7 of 278

1.39

1.79

2.50e-06

MAP-75105

Fatty acyl-CoA biosynthesis

4 of 101

1.59

1.36

0.00086

MAP-556833

Metabolism of lipids

8 of 752

1.01

1.03

3.98e-05

MAP-1430728

Metabolism

9 of 2319

0.58

0.41

0.0090

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0275

Fatty acid biosynthesis

2 of 10

2.29

0.98

0.0152

KW-0249

Electron transport

2 of 18

2.03

0.96

0.0152

KW-0349

Heme

3 of 116

1.4

0.82

0.0152

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00487

Fatty acid desaturase

3 of 10

2.47

1.94

0.00024

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR015876

Acyl-CoA desaturase

3 of 4

2.86

2.24

8.30e-05

IPR005804

Fatty acid desaturase domain

3 of 10

2.47

1.86

0.00034

IPR018506

Cytochrome b5, heme-binding site

3 of 14

2.32

1.74

0.00053

IPR036400

Cytochrome b5-like heme/steroid binding domain superfamily

3 of 26

2.05

1.39

0.0021

IPR001199

Cytochrome b5-like heme/steroid binding domain

3 of 27

2.03

1.38

0.0021

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

3 of 27

2.03

1.52

0.0011

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