ANP46818.1 protein (Caulobacteraceae bacterium OTSzA272)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

ANP46818.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (355 aa)

Predicted Functional Partners:

ANP46819.1

0.783

ANP48077.1

0.779

ANP46817.1

0.580

ANP46820.1

0.478

ANP46825.1

0.449

ANP46827.1

0.409

Your Current Organism:

Caulobacteraceae bacterium OTSzA272

NCBI taxonomy Id: 1759059
Other names: C. bacterium OTSz_A_272, Caulobacteraceae bacterium OTSz_A_272

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANP46817.1	ANP46818.1	ATE48_13290	ATE48_13295	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.580
ANP46817.1	ANP46819.1	ATE48_13290	ATE48_13305	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.610
ANP46817.1	ANP46825.1	ATE48_13290	ATE48_13335	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.429
ANP46817.1	ANP46827.1	ATE48_13290	ATE48_13345	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glycosyl transferase family 2; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.409
ANP46817.1	ANP48077.1	ATE48_13290	ATE48_13300	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Capsule biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.591
ANP46818.1	ANP46817.1	ATE48_13295	ATE48_13290	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.580
ANP46818.1	ANP46819.1	ATE48_13295	ATE48_13305	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.783
ANP46818.1	ANP46820.1	ATE48_13295	ATE48_13310	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.478
ANP46818.1	ANP46825.1	ATE48_13295	ATE48_13335	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.449
ANP46818.1	ANP46827.1	ATE48_13295	ATE48_13345	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glycosyl transferase family 2; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.409
ANP46818.1	ANP48077.1	ATE48_13295	ATE48_13300	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Capsule biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.779
ANP46819.1	ANP46817.1	ATE48_13305	ATE48_13290	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.610
ANP46819.1	ANP46818.1	ATE48_13305	ATE48_13295	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.783
ANP46819.1	ANP46820.1	ATE48_13305	ATE48_13310	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.485
ANP46819.1	ANP46825.1	ATE48_13305	ATE48_13335	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.485
ANP46819.1	ANP46827.1	ATE48_13305	ATE48_13345	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glycosyl transferase family 2; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.483
ANP46819.1	ANP48077.1	ATE48_13305	ATE48_13300	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Capsule biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.831
ANP46820.1	ANP46818.1	ATE48_13310	ATE48_13295	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.478
ANP46820.1	ANP46819.1	ATE48_13310	ATE48_13305	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.485
ANP46820.1	ANP48077.1	ATE48_13310	ATE48_13300	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Capsule biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.478

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.876

expected number of edges:

11

PPI enrichment p-value:

2.4e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045454

Cell redox homeostasis

3 of 20

2.33

1.29

0.0041

GO:0016259

Selenocysteine metabolic process

2 of 2

3.15

1.07

0.0121

GO:0006777

Mo-molybdopterin cofactor biosynthetic process

2 of 8

2.55

0.8

0.0347

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004791

Thioredoxin-disulfide reductase activity

3 of 9

2.68

2.33

5.04e-05

GO:0016783

Sulfurtransferase activity

3 of 10

2.63

2.32

5.04e-05

GO:0015035

Protein-disulfide reductase activity

4 of 37

2.19

2.27

3.53e-05

GO:0070279

Vitamin B6 binding

3 of 53

1.9

1.33

0.0023

GO:0050660

Flavin adenine dinucleotide binding

3 of 82

1.72

1.09

0.0060

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17367

Oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor, and Redox-active center

4 of 13

2.64

3.19

1.05e-06

CL:17369

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain, and Glutathione oxidoreductase activity

2 of 5

2.75

1.21

0.0063

CL:19473

Mitochondrial iron-sulfur cluster biogenesis, and Selenocysteine metabolic process

2 of 8

2.55

1.07

0.0112

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00450

Selenocompound metabolism

6 of 17

2.7

6.38

4.48e-13

map04122

Sulfur relay system

2 of 10

2.45

1.38

0.0029

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2408522

Selenoamino acid metabolism

5 of 22

2.51

4.18

7.96e-09

MAP-3299685

Detoxification of Reactive Oxygen Species

4 of 35

2.21

2.63

6.11e-06

MAP-71291

Metabolism of amino acids and derivatives

6 of 247

1.54

1.95

6.11e-06

MAP-5263617

Metabolism of ingested MeSeO2H into MeSeH

2 of 2

3.15

1.69

0.00090

MAP-499943

Interconversion of nucleotide di- and triphosphates

3 of 40

2.03

1.55

0.00090

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0676

Redox-active center

4 of 15

2.58

3.56

1.77e-07

KW-0663

Pyridoxal phosphate

3 of 38

2.05

1.69

0.00047

KW-0520

NAD

3 of 60

1.85

1.44

0.0012

KW-0274

FAD

3 of 63

1.83

1.43

0.0012

KW-0560

Oxidoreductase

3 of 245

1.24

0.64

0.0342

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02852

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

3 of 5

2.93

2.49

2.86e-05

PF00890

FAD binding domain

3 of 11

2.59

2.18

9.28e-05

PF00070

Pyridine nucleotide-disulphide oxidoreductase

2 of 4

2.85

1.3

0.0044

PF01212

Beta-eliminating lyase

2 of 7

2.61

1.15

0.0080

PF00266

Aminotransferase class-V

2 of 8

2.55

1.15

0.0080

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