node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SSIN_0124 | SSIN_0343 | SSIN_0124 | SSIN_0343 | Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NADP); Belongs to the aldehyde dehydrogenase family. | L-serine dehydratase, beta subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.730 |
SSIN_0124 | SSIN_0344 | SSIN_0124 | SSIN_0344 | Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NADP); Belongs to the aldehyde dehydrogenase family. | L-serine dehydratase, alpha subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.730 |
SSIN_0124 | SSIN_0404 | SSIN_0124 | SSIN_0404 | Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NADP); Belongs to the aldehyde dehydrogenase family. | Cystathionine gamma-synthase. | 0.734 |
SSIN_0124 | SSIN_1332 | SSIN_0124 | SSIN_1332 | Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NADP); Belongs to the aldehyde dehydrogenase family. | Phosphoserine phosphatase. | 0.703 |
SSIN_0124 | SSIN_1973 | SSIN_0124 | SSIN_1973 | Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NADP); Belongs to the aldehyde dehydrogenase family. | Homoserine dehydrogenase. | 0.752 |
SSIN_0124 | glyA | SSIN_0124 | SSIN_1874 | Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NADP); Belongs to the aldehyde dehydrogenase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.732 |
SSIN_0124 | ilvA | SSIN_0124 | SSIN_0845 | Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NADP); Belongs to the aldehyde dehydrogenase family. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.740 |
SSIN_0343 | SSIN_0124 | SSIN_0343 | SSIN_0124 | L-serine dehydratase, beta subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NADP); Belongs to the aldehyde dehydrogenase family. | 0.730 |
SSIN_0343 | SSIN_0344 | SSIN_0343 | SSIN_0344 | L-serine dehydratase, beta subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | L-serine dehydratase, alpha subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.999 |
SSIN_0343 | SSIN_0404 | SSIN_0343 | SSIN_0404 | L-serine dehydratase, beta subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Cystathionine gamma-synthase. | 0.690 |
SSIN_0343 | SSIN_1332 | SSIN_0343 | SSIN_1332 | L-serine dehydratase, beta subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Phosphoserine phosphatase. | 0.697 |
SSIN_0343 | SSIN_1510 | SSIN_0343 | SSIN_1510 | L-serine dehydratase, beta subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine acetyltransferase. | 0.682 |
SSIN_0343 | SSIN_1973 | SSIN_0343 | SSIN_1973 | L-serine dehydratase, beta subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Homoserine dehydrogenase. | 0.693 |
SSIN_0343 | glyA | SSIN_0343 | SSIN_1874 | L-serine dehydratase, beta subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.815 |
SSIN_0343 | ilvA | SSIN_0343 | SSIN_0845 | L-serine dehydratase, beta subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.731 |
SSIN_0343 | metAA | SSIN_0343 | SSIN_0582 | L-serine dehydratase, beta subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.672 |
SSIN_0343 | thrB | SSIN_0343 | SSIN_1974 | L-serine dehydratase, beta subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.710 |
SSIN_0344 | SSIN_0124 | SSIN_0344 | SSIN_0124 | L-serine dehydratase, alpha subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NADP); Belongs to the aldehyde dehydrogenase family. | 0.730 |
SSIN_0344 | SSIN_0343 | SSIN_0344 | SSIN_0343 | L-serine dehydratase, alpha subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | L-serine dehydratase, beta subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.999 |
SSIN_0344 | SSIN_0404 | SSIN_0344 | SSIN_0404 | L-serine dehydratase, alpha subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Cystathionine gamma-synthase. | 0.690 |