node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SSIN_0369 | SSIN_0508 | SSIN_0369 | SSIN_0508 | DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Exodeoxyribonuclease III. | 0.936 |
SSIN_0369 | SSIN_1098 | SSIN_0369 | SSIN_1098 | DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.720 |
SSIN_0369 | ung | SSIN_0369 | SSIN_1841 | DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Uracil-DNA glycosylase, family 1; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.779 |
SSIN_0508 | SSIN_0369 | SSIN_0508 | SSIN_0369 | Exodeoxyribonuclease III. | DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.936 |
SSIN_0508 | nth | SSIN_0508 | SSIN_0504 | Exodeoxyribonuclease III. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.996 |
SSIN_0508 | ung | SSIN_0508 | SSIN_1841 | Exodeoxyribonuclease III. | Uracil-DNA glycosylase, family 1; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.774 |
SSIN_1098 | SSIN_0369 | SSIN_1098 | SSIN_0369 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.720 |
SSIN_1098 | ung | SSIN_1098 | SSIN_1841 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Uracil-DNA glycosylase, family 1; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.430 |
SSIN_1396 | ung | SSIN_1396 | SSIN_1841 | Hypothetical protein. | Uracil-DNA glycosylase, family 1; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.690 |
SSIN_1840 | SSIN_1842 | SSIN_1840 | SSIN_1842 | Membrane protein. | Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase); Belongs to the Nudix hydrolase family. | 0.620 |
SSIN_1840 | pyrC | SSIN_1840 | SSIN_1843 | Membrane protein. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.602 |
SSIN_1840 | pyrE | SSIN_1840 | SSIN_1839 | Membrane protein. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.559 |
SSIN_1840 | ung | SSIN_1840 | SSIN_1841 | Membrane protein. | Uracil-DNA glycosylase, family 1; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.622 |
SSIN_1842 | SSIN_1840 | SSIN_1842 | SSIN_1840 | Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase); Belongs to the Nudix hydrolase family. | Membrane protein. | 0.620 |
SSIN_1842 | SSIN_1844 | SSIN_1842 | SSIN_1844 | Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase); Belongs to the Nudix hydrolase family. | 5'-nucleotidase. | 0.700 |
SSIN_1842 | pyrC | SSIN_1842 | SSIN_1843 | Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase); Belongs to the Nudix hydrolase family. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.773 |
SSIN_1842 | pyrE | SSIN_1842 | SSIN_1839 | Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase); Belongs to the Nudix hydrolase family. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.457 |
SSIN_1842 | ung | SSIN_1842 | SSIN_1841 | Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase); Belongs to the Nudix hydrolase family. | Uracil-DNA glycosylase, family 1; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.792 |
SSIN_1844 | SSIN_1842 | SSIN_1844 | SSIN_1842 | 5'-nucleotidase. | Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase); Belongs to the Nudix hydrolase family. | 0.700 |
SSIN_1844 | pyrC | SSIN_1844 | SSIN_1843 | 5'-nucleotidase. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.583 |