Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SSIN_1996Hydroxymethylglutaryl-CoA reductase; Belongs to the HMG-CoA reductase family. (427 aa)    
Predicted Functional Partners:
SSIN_1995
Hydroxymethylglutaryl-CoA synthase.
 
 0.999
SSIN_2000
Mevalonate kinase.
 0.995
SSIN_1999
Diphosphomevalonate decarboxylase.
 
 
 0.939
SSIN_1998
Phosphomevalonate kinase.
 
 0.935
fni
Isopentenyl-diphosphate delta-isomerase, FMN-dependent; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
   
 0.916
SSIN_0051
Octaprenyl-diphosphate synthase; Dimethylallyltransferase; Geranyltranstransferase (farnesyldiphosphate synthase); Geranylgeranyl pyrophosphate synthetase; Belongs to the FPP/GGPP synthase family.
  
 
 0.747
ldh
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.
   
  
 0.690
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
    
 0.639
SSIN_1994
Membrane spanning protein.
       0.627
SSIN_1993
Hypothetical protein; FIG01116603.
       0.626
Your Current Organism:
Streptococcus sinensis
NCBI taxonomy Id: 176090
Other names: CCUG 48363, CCUG 48488, DSM 14990, LMG 21517, LMG:21517, S. sinensis, Streptococcus sinensis Woo et al. 2002, strain HKU4
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