Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
spoVGspoVG protein; Could be involved in septation. (102 aa)    
Predicted Functional Partners:
SERP0135
Endoribonuclease L-PSP, putative; Identified by match to protein family HMM PF01042; match to protein family HMM TIGR00004.
     
 0.838
purR
Pur operon repressor; Identified by similarity to EGAD:16043; match to protein family HMM PF00156; match to protein family HMM TIGR01743.
 
   
 0.837
ispE
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol; Belongs to the GHMP kinase family. IspE subfamily.
       0.688
pth
peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.
 
   
 0.639
smpB
SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...]
      
 0.514
rpoF
RNA polymerase sigma-37 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
  
 0.453
SERP0119
Orn/Lys/Arg decarboxylase; Identified by match to protein family HMM PF01276.
 
     0.422
ccpA
Catabolite control protein A; Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions.
    
 
 0.416
SERP0132
Conserved hypothetical protein; Identified by similarity to OMNI:SA0537.
       0.413
prsA
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
       0.401
Your Current Organism:
Staphylococcus epidermidis
NCBI taxonomy Id: 176279
Other names: S. epidermidis RP62A, Staphylococcus epidermidis ATCC 35984, Staphylococcus epidermidis RP62A, Staphylococcus epidermidis str. RP62A, Staphylococcus epidermidis strain RP62A
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