| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SERP0163 | clpB | SERP0163 | SERP0564 | UvrB/UvrC domain protein; Identified by match to protein family HMM PF02151. | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to [...] | 0.614 |
| SERP0163 | clpC | SERP0163 | SERP0165 | UvrB/UvrC domain protein; Identified by match to protein family HMM PF02151. | ATP-dependent Clp protease, ATP-binding subunit ClpC; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. | 0.949 |
| SERP0163 | clpP | SERP0163 | SERP0436 | UvrB/UvrC domain protein; Identified by match to protein family HMM PF02151. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.498 |
| SERP0163 | ctsR | SERP0163 | SERP0162 | UvrB/UvrC domain protein; Identified by match to protein family HMM PF02151. | Transcriptional regulator CtsR; Negative regulator of clpC, clpB and clpP transcription by binding directly and specifically to their promoter region. | 0.997 |
| SERP0163 | mcsB | SERP0163 | SERP0164 | UvrB/UvrC domain protein; Identified by match to protein family HMM PF02151. | ATP:guanido phosphotransferase family protein; Catalyzes the specific phosphorylation of arginine residues in proteins; Belongs to the ATP:guanido phosphotransferase family. | 0.999 |
| SERP0163 | nupC | SERP0163 | SERP0161 | UvrB/UvrC domain protein; Identified by match to protein family HMM PF02151. | Nucleoside permease NupC; Identified by similarity to EGAD:30360; match to protein family HMM PF01773. | 0.750 |
| SERP0163 | ptpB | SERP0163 | SERP1721 | UvrB/UvrC domain protein; Identified by match to protein family HMM PF02151. | Phosphotyrosine protein phosphatase; Dephosphorylates the phosphotyrosine-containing proteins. Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | 0.831 |
| SERP0163 | radA | SERP0163 | SERP0166 | UvrB/UvrC domain protein; Identified by match to protein family HMM PF02151. | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | 0.562 |
| clpB | SERP0163 | SERP0564 | SERP0163 | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to [...] | UvrB/UvrC domain protein; Identified by match to protein family HMM PF02151. | 0.614 |
| clpB | clpP | SERP0564 | SERP0436 | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to [...] | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.972 |
| clpB | clpX | SERP0564 | SERP1238 | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to [...] | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.695 |
| clpB | ctsR | SERP0564 | SERP0162 | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to [...] | Transcriptional regulator CtsR; Negative regulator of clpC, clpB and clpP transcription by binding directly and specifically to their promoter region. | 0.846 |
| clpB | mcsB | SERP0564 | SERP0164 | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to [...] | ATP:guanido phosphotransferase family protein; Catalyzes the specific phosphorylation of arginine residues in proteins; Belongs to the ATP:guanido phosphotransferase family. | 0.706 |
| clpB | mecA-2 | SERP0564 | SERP0578 | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to [...] | Negative regulator of competence MecA, putative; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. | 0.907 |
| clpC | SERP0163 | SERP0165 | SERP0163 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. | UvrB/UvrC domain protein; Identified by match to protein family HMM PF02151. | 0.949 |
| clpC | clpP | SERP0165 | SERP0436 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.993 |
| clpC | clpX | SERP0165 | SERP1238 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.814 |
| clpC | ctsR | SERP0165 | SERP0162 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. | Transcriptional regulator CtsR; Negative regulator of clpC, clpB and clpP transcription by binding directly and specifically to their promoter region. | 0.984 |
| clpC | mcsB | SERP0165 | SERP0164 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. | ATP:guanido phosphotransferase family protein; Catalyzes the specific phosphorylation of arginine residues in proteins; Belongs to the ATP:guanido phosphotransferase family. | 0.990 |
| clpC | mecA-2 | SERP0165 | SERP0578 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. | Negative regulator of competence MecA, putative; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. | 0.933 |
