STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sarAStaphylococcal accessory regulator A; Identified by similarity to EGAD:42500; match to protein family HMM TIGR01889. (124 aa)    
Predicted Functional Partners:
icaR
Intercellular adhesion regulator; Represses transcription of the icaADBC operon necessary for biofilm production.
      
 0.849
icaA
Intercellular adhesion protein A; N-acetylglucosaminyltransferase that catalyzes the polymerization of single monomer units of UDP-N-acetylglucosamine to produce the linear homopolymer poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide. Requires IcaD for full activity.
   
  
 0.833
sarZ
Transcriptional regulator, MarR family; Identified by match to protein family HMM PF01047.
      
 0.815
rsbU
Sigma factor B regulator protein; Identified by similarity to GP:1729794.
   
  
 0.769
sarX
Staphylococcal accessory regulator family; Identified by match to protein family HMM TIGR01889.
      
 0.760
srrA
DNA-binding response regulator SrrA; Identified by similarity to EGAD:14175; similarity to OMNI:SA1535; match to protein family HMM PF00072; match to protein family HMM PF00486.
   
  
 0.758
atlE
Bifunctional autolysin; Endohydrolysis of the di-N-acetylchitobiosyl unit in high- mannose glycopeptides and glycoproteins containing the -[(Man)5(GlcNAc)2]-Asn structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis (By similarity); In the C-terminal section; belongs to the glycosyl hydrolase 73 family.
     
 0.723
icaD
Intercellular adhesion protein D; Necessary for the synthesis of poly-beta-1,6-N-acetyl-D- glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide. Is required for full IcaA N- acetylglucosaminyltransferase activity.
      
 0.658
tcaR
Transcriptional regulator TcaR; Identified by similarity to OMNI:SA2353; match to protein family HMM PF01047.
      
 0.620
agrB
Accessory gene regulator protein B; Essential for the production of a quorum sensing system signal molecule, the autoinducing peptide (AIP). This quorum sensing system is responsible for the regulation of the expression of virulence factor genes. Involved in the proteolytic processing of AgrD, the precursor of AIP; Belongs to the AgrB family.
      
 0.612
Your Current Organism:
Staphylococcus epidermidis
NCBI taxonomy Id: 176279
Other names: S. epidermidis RP62A, Staphylococcus epidermidis ATCC 35984, Staphylococcus epidermidis RP62A, Staphylococcus epidermidis str. RP62A, Staphylococcus epidermidis strain RP62A
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