STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
graSSensor histidine kinase; Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs). GraS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to GraR (By similarity). (346 aa)    
Predicted Functional Partners:
graR
DNA-binding response regulator; Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs).
 
 0.999
SERP0315
ABC transporter, permease protein; Identified by match to protein family HMM PF02687.
 
 
 0.988
phoP
Alkaline phosphatase synthesis transcriptional regulatory protein PhoP; Identified by similarity to EGAD:18490; match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 
 0.925
SERP2206
DNA-binding response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 
 0.894
arlR
DNA-binding response regulator ArlR; Member of the two-component regulatory system ArlS/ArlR.
 
 
 0.842
SERP0311
Conserved hypothetical protein; Identified by similarity to OMNI:SA0715.
  
  
 0.839
saeR
DNA-binding response regulator SaeR; Member of the two-component regulatory system SaeR/SaeS. Probably functions as a transcriptional regulator via a specific DNA- binding domain, recognizing motifs near the promoter sequences of target genes (By similarity).
 
 
 0.837
yycF
DNA-binding response regulator YycF; Member of the two-component regulatory system WalK/WalR.
 
 
 0.836
srrA
DNA-binding response regulator SrrA; Identified by similarity to EGAD:14175; similarity to OMNI:SA1535; match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 
 0.830
kdeP
DNA-binding response regulator KdeP; Identified by similarity to EGAD:91700; match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 
 0.821
Your Current Organism:
Staphylococcus epidermidis
NCBI taxonomy Id: 176279
Other names: S. epidermidis RP62A, Staphylococcus epidermidis ATCC 35984, Staphylococcus epidermidis RP62A, Staphylococcus epidermidis str. RP62A, Staphylococcus epidermidis strain RP62A
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