Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
Experiments
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[Homology]
Score
graSSensor histidine kinase; Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs). GraS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to GraR (By similarity). (346 aa)    
Predicted Functional Partners:
graR
DNA-binding response regulator; Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs).
 
 0.999
SERP0315
ABC transporter, permease protein; Identified by match to protein family HMM PF02687.
 
 
 0.992
phoP
Alkaline phosphatase synthesis transcriptional regulatory protein PhoP; Identified by similarity to EGAD:18490; match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 
 0.900
SERP2206
DNA-binding response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486.
 
   0.890
SERP0020
ABC transporter, permease protein; Identified by similarity to OMNI:NTL01BH0754; match to protein family HMM PF02687.
 
 
 
 0.876
SERP0314
ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005.
 
 
 0.869
arlR
DNA-binding response regulator ArlR; Member of the two-component regulatory system ArlS/ArlR.
 
 
 0.860
hssR
DNA-binding response regulator; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated HssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity).
 
 
 0.858
saeR
DNA-binding response regulator SaeR; Member of the two-component regulatory system SaeR/SaeS. Probably functions as a transcriptional regulator via a specific DNA- binding domain, recognizing motifs near the promoter sequences of target genes (By similarity).
 
 
 0.846
yycF
DNA-binding response regulator YycF; Member of the two-component regulatory system WalK/WalR.
 
 
 0.841
Your Current Organism:
Staphylococcus epidermidis
NCBI taxonomy Id: 176279
Other names: S. epidermidis RP62A, Staphylococcus epidermidis ATCC 35984, Staphylococcus epidermidis RP62A, Staphylococcus epidermidis str. RP62A, Staphylococcus epidermidis strain RP62A
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