| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SERP0517 | dltA | SERP0517 | SERP0518 | Conserved hypothetical protein; Identified by similarity to OMNI:NTL01SA0820. | D-alanine-activating enzyme; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP [...] | 0.876 |
| SERP0517 | dltB | SERP0517 | SERP0519 | Conserved hypothetical protein; Identified by similarity to OMNI:NTL01SA0820. | dltB protein; Could be involved in the transport of activated D-alanine through the membrane. | 0.876 |
| SERP0517 | dltC | SERP0517 | SERP0520 | Conserved hypothetical protein; Identified by similarity to OMNI:NTL01SA0820. | D-alanyl carrier protein; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. | 0.869 |
| SERP0517 | dltD | SERP0517 | SERP0521 | Conserved hypothetical protein; Identified by similarity to OMNI:NTL01SA0820. | dltD protein; Identified by match to protein family HMM PF04914; match to protein family HMM PF04915; match to protein family HMM PF04918. | 0.869 |
| SERP0969 | SERP2338 | SERP0969 | SERP2338 | Alanine racemase family protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Peptide synthetase; Identified by match to protein family HMM PF00501; match to protein family HMM PF00550; match to protein family HMM PF00668; match to protein family HMM TIGR01733; match to protein family HMM TIGR01746; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.404 |
| SERP0969 | alr | SERP0969 | SERP1683 | Alanine racemase family protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.927 |
| SERP0969 | dat | SERP0969 | SERP1309 | Alanine racemase family protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | D-alanine aminotransferase; Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha-keto acid in the first half-reaction. The second half-reaction is the reverse of the first, transferring the amino group from the pyridoxamine to a second alpha-keto acid to form the product D-amino acid via a ping-pong mechanism. This is an important process in the formation of D-alanine and D-glutamate, which are essen [...] | 0.920 |
| SERP0969 | ddl | SERP0969 | SERP1690 | Alanine racemase family protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | D-alanine--D-alanine ligase; Cell wall formation. | 0.944 |
| SERP0969 | dltA | SERP0969 | SERP0518 | Alanine racemase family protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | D-alanine-activating enzyme; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP [...] | 0.912 |
| SERP0969 | dltC | SERP0969 | SERP0520 | Alanine racemase family protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | D-alanyl carrier protein; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. | 0.902 |
| SERP2338 | SERP0969 | SERP2338 | SERP0969 | Peptide synthetase; Identified by match to protein family HMM PF00501; match to protein family HMM PF00550; match to protein family HMM PF00668; match to protein family HMM TIGR01733; match to protein family HMM TIGR01746; Belongs to the ATP-dependent AMP-binding enzyme family. | Alanine racemase family protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.404 |
| SERP2338 | alr | SERP2338 | SERP1683 | Peptide synthetase; Identified by match to protein family HMM PF00501; match to protein family HMM PF00550; match to protein family HMM PF00668; match to protein family HMM TIGR01733; match to protein family HMM TIGR01746; Belongs to the ATP-dependent AMP-binding enzyme family. | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.404 |
| SERP2338 | dat | SERP2338 | SERP1309 | Peptide synthetase; Identified by match to protein family HMM PF00501; match to protein family HMM PF00550; match to protein family HMM PF00668; match to protein family HMM TIGR01733; match to protein family HMM TIGR01746; Belongs to the ATP-dependent AMP-binding enzyme family. | D-alanine aminotransferase; Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha-keto acid in the first half-reaction. The second half-reaction is the reverse of the first, transferring the amino group from the pyridoxamine to a second alpha-keto acid to form the product D-amino acid via a ping-pong mechanism. This is an important process in the formation of D-alanine and D-glutamate, which are essen [...] | 0.429 |
| SERP2338 | dltA | SERP2338 | SERP0518 | Peptide synthetase; Identified by match to protein family HMM PF00501; match to protein family HMM PF00550; match to protein family HMM PF00668; match to protein family HMM TIGR01733; match to protein family HMM TIGR01746; Belongs to the ATP-dependent AMP-binding enzyme family. | D-alanine-activating enzyme; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP [...] | 0.884 |
| SERP2338 | dltB | SERP2338 | SERP0519 | Peptide synthetase; Identified by match to protein family HMM PF00501; match to protein family HMM PF00550; match to protein family HMM PF00668; match to protein family HMM TIGR01733; match to protein family HMM TIGR01746; Belongs to the ATP-dependent AMP-binding enzyme family. | dltB protein; Could be involved in the transport of activated D-alanine through the membrane. | 0.993 |
| SERP2338 | dltC | SERP2338 | SERP0520 | Peptide synthetase; Identified by match to protein family HMM PF00501; match to protein family HMM PF00550; match to protein family HMM PF00668; match to protein family HMM TIGR01733; match to protein family HMM TIGR01746; Belongs to the ATP-dependent AMP-binding enzyme family. | D-alanyl carrier protein; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. | 0.870 |
| SERP2338 | dltD | SERP2338 | SERP0521 | Peptide synthetase; Identified by match to protein family HMM PF00501; match to protein family HMM PF00550; match to protein family HMM PF00668; match to protein family HMM TIGR01733; match to protein family HMM TIGR01746; Belongs to the ATP-dependent AMP-binding enzyme family. | dltD protein; Identified by match to protein family HMM PF04914; match to protein family HMM PF04915; match to protein family HMM PF04918. | 0.978 |
| SERP2338 | fabD | SERP2338 | SERP0796 | Peptide synthetase; Identified by match to protein family HMM PF00501; match to protein family HMM PF00550; match to protein family HMM PF00668; match to protein family HMM TIGR01733; match to protein family HMM TIGR01746; Belongs to the ATP-dependent AMP-binding enzyme family. | Malonyl CoA-acyl carrier protein transacylase; Identified by match to protein family HMM PF00698; match to protein family HMM TIGR00128. | 0.959 |
| alr | SERP0969 | SERP1683 | SERP0969 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Alanine racemase family protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.927 |
| alr | SERP2338 | SERP1683 | SERP2338 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Peptide synthetase; Identified by match to protein family HMM PF00501; match to protein family HMM PF00550; match to protein family HMM PF00668; match to protein family HMM TIGR01733; match to protein family HMM TIGR01746; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.404 |