Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
mntHMn2+/Fe2+ transporter, NRAMP family; H(+)-stimulated, divalent metal cation uptake system. Belongs to the NRAMP family. (453 aa)    
Predicted Functional Partners:
sitB
ABC transporter, permease protein; Identified by match to protein family HMM PF00950.
  
  
 0.836
blaI-1
Penicillinase repressor; Identified by similarity to EGAD:13370; match to protein family HMM PF03965.
      
 0.813
blaR1-1
Regulatory protein BlaR1; Identified by similarity to SP:P18357; match to protein family HMM PF00144; match to protein family HMM PF00905; match to protein family HMM PF05569.
      
 0.758
copB
Cation-transporting ATPase, E1-E2 family; Involved in copper transport.
  
 
 0.755
sirR
Iron-dependent repressor; Identified by similarity to GP:1617434; match to protein family HMM PF01325; match to protein family HMM PF02742.
 
  
 0.725
SERP0693
Conserved hypothetical protein; Identified by similarity to OMNI:NTL02SA1097; Belongs to the UPF0637 family.
       0.692
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
  
  
 0.689
sodA
Superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
      
 0.640
sitC
ABC transporter, substrate-binding protein; Identified by similarity to GP:1617430; match to protein family HMM PF01297; Belongs to the bacterial solute-binding protein 9 family.
  
  
 0.609
sitA
ABC transporter, ATP-binding protein; Identified by similarity to GP:1617428; match to protein family HMM PF00005.
  
  
 0.598
Your Current Organism:
Staphylococcus epidermidis
NCBI taxonomy Id: 176279
Other names: S. epidermidis RP62A, Staphylococcus epidermidis ATCC 35984, Staphylococcus epidermidis RP62A, Staphylococcus epidermidis str. RP62A, Staphylococcus epidermidis strain RP62A
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