Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SERP0732Succinate dehydrogenase, iron-sulfur protein; Identified by similarity to SP:P08066; match to protein family HMM PF00037; match to protein family HMM PF00111; match to protein family HMM TIGR00384. (280 aa)    
Predicted Functional Partners:
sdhC
Succinate dehydrogenase, cytochrome b558 subunit; Identified by similarity to EGAD:20778.
 
 0.999
SERP0731
Succinate dehydrogenase, flavoprotein subunit; Identified by similarity to SP:P08065; match to protein family HMM PF00890; match to protein family HMM PF02910; match to protein family HMM TIGR01811.
 
 0.999
sucD
succinyl-CoA synthase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
 0.991
sucC
succinyl-CoA synthase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 0.985
fumC
Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.971
SERP2381
NADH:flavin oxidoreductase/fumarate reductase, flavoprotein subunit, putative; Identified by similarity to EGAD:16535; match to protein family HMM PF00724; match to protein family HMM PF00890; match to protein family HMM PF04205; match to protein family HMM TIGR01813.
  
 0.969
sucA
2-oxoglutarate dehydrogenase, E1 component; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
  
 
 0.839
argH
Argininosuccinate lyase; Identified by similarity to EGAD:108136; match to protein family HMM PF00206; match to protein family HMM TIGR00838.
    
 0.815
qoxA
Quinol oxidase, subunit I; Catalyzes quinol oxidation with the concomitant reduction of oxygen to water.
   
 
 0.801
atpG
ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
  
 
 0.796
Your Current Organism:
Staphylococcus epidermidis
NCBI taxonomy Id: 176279
Other names: S. epidermidis RP62A, Staphylococcus epidermidis ATCC 35984, Staphylococcus epidermidis RP62A, Staphylococcus epidermidis str. RP62A, Staphylococcus epidermidis strain RP62A
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